36 Result(s)

Chapter

Relative Intrinsic Potency of Asbestos and Erionite Fibers: Proposed Mechanism of Action

Data from human exposure to naturally occurring mineral fibers indicates extreme variability in the rate of mesothelioma between various asbestos varieties and erionite. Experiments on rats have confirmed thes...

David L. Coffin, Andrew J. Ghio in Mechanisms in Fibre Carcinogenesis (1991)

Article

Hypothesis: Iron chelation plays a vital role in neutrophilic inflammation

Neutrophil influx into tissues occurs in many diverse diseases and can be associated with both beneficial and injurious effects. We hypothesize that the stimulus for certain neutrophilic inflammatory responses...

Andrew J. Ghio, Claude A. Piantadosi, Alvin L. Crumbliss in Biometals (1997)

Article

The release of iron from different asbestos structures by hydrogen peroxide with concomitant O generation

Treatment of aqueous suspensions of different asbestos fibers (amosite, anthophyllite, chrysotile, and crocidolite) at 0-4°C and pH 7.2 with H O results in the consumption of H O with concomitant release of ir...

Andrew J. Ghio, David E. Taylor, Jacqueline G. Stonehuerner… in Biometals (1998)

Article

DMT1: A mammalian transporter for multiple metals

DMT1 has four names, transports as many as eight metals, may have four or more isoforms and carries out its transport for multiple purposes. This review is a start at sorting out these multiplicities. A G185R ...

Michael D. Garrick, Kevin G. Dolan, Craig Horbinski, Andrew J. Ghio… in Biometals (2003)

Article

Exercise-Induced Pulmonary Hemorrhage After Running a Marathon

We report on a healthy 26-year-old male who had an exercise-induced pulmonary hemorrhage (EIPH) within 24 hours of running a marathon. There were no symptoms, abnormalities on exam, or radiographic infiltrates...

Andrew J. Ghio, Christine Ghio, Maryann Bassett in Lung (2006)

Article

Panel discussion review: session four — assessing biological plausibility of epidemiological findings in air pollution research

In December 2006, the U.S. Environmental Protection Agency (EPA) sponsored a 2-day workshop on “Interpretation of Epidemiologic Studies of Multipollutant Exposure and Health Effects” in Chapel Hill, NC. The fi...

James S Brown, Judith A Graham… in Journal of Exposure Science & Environmenta… (2007)

Article

Iron accumulation in bronchial epithelial cells is dependent on concurrent sodium transport

Airway epithelial cells prevent damaging effects of extracellular iron by taking up the metal and sequestering it within intracellular ferritin. Epithelial iron transport is associated with transcellular movem...

Jennifer L. Turi, Claude A. Piantadosi, Jackie D. Stonehuerner, Andrew J. Ghio in BioMetals (2008)

Article

Zinc transport by respiratory epithelial cells and interaction with iron homeostasis

Despite recurrent exposure to zinc through inhalation of ambient air pollution particles, relatively little information is known about the homeostasis of this metal in respiratory epithelial cells. We describe...

Zhong** Deng, Lisa A. Dailey, Joleen Soukup, Jacqueline Stonehuerner… in BioMetals (2009)

Article

Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumes

The potential for development of Parkinson’s disease (PD)-like neurological dysfunction following occupational exposure to aerosolized welding fumes (WF) is an area of emerging concern. Welding consumables con...

Krishnan Sriram, Gary X. Lin, Amy M. Jefferson, Jenny R. Roberts… in Archives of Toxicology (2010)

Article

Deficiency in the divalent metal transporter 1 increases bleomycin-induced lung injury

Exposure to bleomycin can result in an inflammatory lung injury. The biological effect of this anti-neoplastic agent is dependent on its coordination of iron with subsequent oxidant generation. In lung cells, ...

Funmei Yang, Jacqueline G. Stonehuerner, Judy H. Richards, Ngoc-Bich Nguyen… in BioMetals (2010)

Article

Gadolinium exposure disrupts iron homeostasis in cultured cells

Human exposure to gadolinium-based contrast agents can be complicated by nephrogenic systemic fibrosis (NSF). Demonstration of significant quantities of insoluble gadolinium in the skin of NSF patients suggest...

Andrew J. Ghio, Joleen M. Soukup… in JBIC Journal of Biological Inorganic Chemi… (2011)

Chapter

Pneumoconiosis in the Twenty-First Century

While defined pathologically, it is uncommon that the diagnosis of pneumoconiosis necessitates tissue biopsy. The approach initially used by physicians for diagnosis of asbestosis has been extrapolated to all ...

Andrew J. Ghio in A Clinical Guide to Occupational and Environmental Lung Diseases (2012)

Article

Anemia and global iron fortification and supplementation

Andrew J. Ghio in Annals of Hematology (2012)

Chapter

Oxidative Injury Caused by Cigarette Smoking and Air Pollution

Oxidative stress is pivotal to the biological effects, tissue injury, and disease following exposures to both cigarette smoke and air pollutants. Cigarette smoke and air pollutants can directly generate oxidan...

Andrew J. Ghio in Studies on Respiratory Disorders (2014)