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10 Result(s)
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Article
Open AccessMonitoring redox stress in human airway epithelial cells exposed to woodsmoke at an air–liquid interface
Wildland fires contribute significantly to the ambient air pollution burden worldwide, causing a range of adverse health effects in exposed populations. The toxicity of woodsmoke, a complex mixture of gases, v...
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Article
Open AccessInterstitial lung abnormalities and interstitial lung diseases associated with cigarette smoking in a rural cohort undergoing surgical resection
Cigarette smoking is a risk factor for interstitial lung abnormalities (ILAs) and interstitial lung diseases (ILDs). Investigation defining the relationships between ILAs/ILDs and clinical, radiographic, and p...
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Article
Open AccessIn vitro determinants of asbestos fiber toxicity: effect on the relative toxicity of Libby amphibole in primary human airway epithelial cells
An abnormally high incidence of lung disease has been observed in the residents of Libby, Montana, which has been attributed to occupational and environmental exposure to fibrous amphiboles originating from a ...
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Chapter
Oxidative Injury Caused by Cigarette Smoking and Air Pollution
Oxidative stress is pivotal to the biological effects, tissue injury, and disease following exposures to both cigarette smoke and air pollutants. Cigarette smoke and air pollutants can directly generate oxidan...
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Article
Open AccessGrowth of human bronchial epithelial cells at an air-liquid interface alters the response to particle exposure
We tested the hypothesis that normal human bronchial epithelial (NHBE) cells 1) grown submerged in media and 2) allowed to differentiate at air-liquid interface (ALI) demonstrate disparities in the response to...
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Book
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Chapter
Pneumoconiosis in the Twenty-First Century
While defined pathologically, it is uncommon that the diagnosis of pneumoconiosis necessitates tissue biopsy. The approach initially used by physicians for diagnosis of asbestosis has been extrapolated to all ...
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Article
Open AccessHepcidin expression in human airway epithelial cells is regulated by interferon-γ
Hepcidin serves as a major regulator of systemic iron metabolism and immune function. Airway epithelial cells have an extensive interface with the environment, and so must be able to respond locally to the pre...
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Article
Open AccessIron homeostasis and oxidative stress in idiopathic pulmonary alveolar proteinosis: a case-control study
Lung injury caused by both inhaled dusts and infectious agents depends on increased availability of iron and metal-catalyzed oxidative stress. Because inhaled particles, such as silica, and certain infections ...
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Article
Exercise-Induced Pulmonary Hemorrhage After Running a Marathon
We report on a healthy 26-year-old male who had an exercise-induced pulmonary hemorrhage (EIPH) within 24 hours of running a marathon. There were no symptoms, abnormalities on exam, or radiographic infiltrates...
