11 Result(s)
within
Andrew J. Ghio
Microbiology
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Article
Cyanobacterial blooms, iron, and environmental pollutants
Iron determines the abundance and diversity of life and controls primary production in numerous aqueous environments. Over the past decades, the availability of this metal in natural waters has decreased. Iron...
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Iron and zinc homeostases in female rats with physically active and sedentary lifestyles
To determine the effects of repeated physical activity on iron and zinc homeostases in a living system, we quantified blood and tissue levels of these two metals in sedentary and physically active Long-Evans r...
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Open AccessA direct comparison of divalent metal-ion transporter (DMT1) and hinokitiol, a potential small molecule replacement
Hinokitiol, a natural lipophilic chelator, appears capable of replacing several iron transporters after they have been genetically ablated. Divalent metal-ion transporter (DMT1) is the major iron importer in e...
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Asthma as a disruption in iron homeostasis
Over several decades, asthma has evolved from being recognized as a single disease to include a diverse group of phenotypes with dissimilar natural histories, pathophysiologies, responses to treatment, and dis...
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Gadolinium exposure disrupts iron homeostasis in cultured cells
Human exposure to gadolinium-based contrast agents can be complicated by nephrogenic systemic fibrosis (NSF). Demonstration of significant quantities of insoluble gadolinium in the skin of NSF patients suggest...
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Deficiency in the divalent metal transporter 1 increases bleomycin-induced lung injury
Exposure to bleomycin can result in an inflammatory lung injury. The biological effect of this anti-neoplastic agent is dependent on its coordination of iron with subsequent oxidant generation. In lung cells, ...
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Zinc transport by respiratory epithelial cells and interaction with iron homeostasis
Despite recurrent exposure to zinc through inhalation of ambient air pollution particles, relatively little information is known about the homeostasis of this metal in respiratory epithelial cells. We describe...
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Iron accumulation in bronchial epithelial cells is dependent on concurrent sodium transport
Airway epithelial cells prevent damaging effects of extracellular iron by taking up the metal and sequestering it within intracellular ferritin. Epithelial iron transport is associated with transcellular movem...
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DMT1: A mammalian transporter for multiple metals
DMT1 has four names, transports as many as eight metals, may have four or more isoforms and carries out its transport for multiple purposes. This review is a start at sorting out these multiplicities. A G185R ...
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The release of iron from different asbestos structures by hydrogen peroxide with concomitant O generation
Treatment of aqueous suspensions of different asbestos fibers (amosite, anthophyllite, chrysotile, and crocidolite) at 0-4°C and pH 7.2 with H O results in the consumption of H O with concomitant release of ir...
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Hypothesis: Iron chelation plays a vital role in neutrophilic inflammation
Neutrophil influx into tissues occurs in many diverse diseases and can be associated with both beneficial and injurious effects. We hypothesize that the stimulus for certain neutrophilic inflammatory responses...
