-
Article
Open AccessEffectiveness of e-cigarettes as a stop smoking intervention in adults: a systematic review
This systematic review aims to identify the benefits and harms of electronic cigarettes (e-cigarettes) as a smoking cessation aid in adults (aged ≥ 18 years) and to inform the development of the Canadian Task ...
-
Article
Open AccessScreening for depression in children and adolescents in primary care or non-mental health settings: a systematic review update
The transition from childhood to adolescence is associated with an increase in rates of some psychiatric disorders, including major depressive disorder, a debilitating mood disorder. The aim of this systematic...
-
Article
Open AccessScreening for hypertension in adults: protocol for evidence reviews to inform a Canadian Task Force on Preventive Health Care guideline update
To inform updated recommendations by the Canadian Task Force on Preventive Health Care on screening in a primary care setting for hypertension in adults aged 18 years and older. This protocol outlines the scop...
-
Article
Open AccessScreening for prostate cancer: protocol for updating multiple systematic reviews to inform a Canadian Task Force on Preventive Health Care guideline update
To inform updated recommendations by the Canadian Task Force on Preventive Health Care on screening for prostate cancer in adults aged 18 years and older in primary care. This protocol outlines the planned sco...
-
Article
Open AccessInterventions to address potentially inappropriate prescriptions and over-the-counter medication use among adults 65 years and older in primary care settings: protocol for a systematic review
To inform recommendations by the Canadian Task Force on Preventive Health Care on potentially inappropriate prescribing and over-the-counter (OTC) medication use among adults aged 65 years and older in primary...
-
Article
Open AccessScreening for depression among the general adult population and in women during pregnancy or the first-year postpartum: two systematic reviews to inform a guideline of the Canadian Task Force on Preventive Health Care
Depression affects an individual’s physical health and mental well-being and, in pregnant and postpartum women, has specific adverse short- and long-term effects on maternal, child, and family health. The aim ...
-
Article
Open AccessEvaluations of postoperative transitions in care for older adults: a sco** review
Most people having major surgery are over the age of 65. The transition out of hospital is a vulnerable time for older adults, particularly after major surgery. Research on postoperative transitions in care is...
-
Article
Open AccessScreening for depression in children and adolescents: a protocol for a systematic review update
Major depressive disorder is common, debilitating, and affects feelings, thoughts, mood, and behaviors. Childhood and adolescence are critical periods for the development of depression and adolescence is marke...
-
Article
Open AccessScreening for esophageal adenocarcinoma and precancerous conditions (dysplasia and Barrett’s esophagus) in patients with chronic gastroesophageal reflux disease with or without other risk factors: two systematic reviews and one overview of reviews to inform a guideline of the Canadian Task Force on Preventive Health Care (CTFPHC)
Two reviews and an overview were produced for the Canadian Task Force on Preventive Health Care guideline on screening for esophageal adenocarcinoma in patients with chronic gastroesophageal reflux disease (GE...
-
Article
Open AccessApplication of convolutional neural networks to breast biopsies to delineate tissue correlates of mammographic breast density
Breast density, a breast cancer risk factor, is a radiologic feature that reflects fibroglandular tissue content relative to breast area or volume. Its histology is incompletely characterized. Here we use deep...
-
Article
Open AccessEffectiveness of stop smoking interventions among adults: protocol for an overview of systematic reviews and an updated systematic review
Tobacco smoking is the leading cause of cancer, preventable death, and disability. Smoking cessation can increase life expectancy by nearly a decade if achieved in the third or fourth decades of life. Various ...
-
Article
Open AccessScreening for depression in women during pregnancy or the first year postpartum and in the general adult population: a protocol for two systematic reviews to update a guideline of the Canadian Task Force on Preventive Health Care
In 2018, the World Health Organization reported that depression is the most common cause of disability worldwide, with over 300 million people currently living with depression. Depression affects an individual...
-
Article
Open AccessAnesthesia interventions that alter perioperative mortality: a sco** review
With over 230 million surgical procedures performed annually worldwide, better application of evidence in anesthesia and perioperative medicine may reduce widespread variation in clinical practice and improve ...
-
Article
Stop this waste of people, animals and money
Predatory journals have shoddy reporting and include papers from wealthy nations, find David Moher, Larissa Shamseer, Kelly Cobey and colleagues.
-
Article
Peer-Assisted Learning in Introductory Histopathology Improves Learner Scores and Delivers Learner Satisfaction
Peer-assisted learning (PAL) is learning facilitated by non-professional teachers who are members of the same peer or near-peer group as learners. The authors designed and implemented PAL for teaching histopat...
-
Article
Open AccessEvaluating the concordance between sequencing, imputation and microarray genotype calls in the GAW18 data
Genotype errors are well known to increase type I errors and/or decrease power in related tests of genotype-phenotype association, depending on whether the genotype error mechanism is associated with the pheno...
-
Article
Open AccessEvaluation of the power and type I error of recently proposed family-based tests of association for rare variants
Until very recently, few methods existed to analyze rare-variant association with binary phenotypes in complex pedigrees. We consider a set of recently proposed methods applied to the simulated and real hypert...
-
Article
Open AccessApplication of family-based tests of association for rare variants to pathways
Pathway analysis approaches for sequence data typically either operate in a single stage (all variants within all genes in the pathway are combined into a single, very large set of variants that can then be an...
-
Article
Evolutionary origin and development of snake fangs
An 'evo-devo' study of venomous snakes has arrived at a new model for the evolution of snake fangs, a subject of some controversy. Many of the advanced snakes alive today use syringe-like fangs to inject venom...
-
Article
Simulation: the practice of model development and use
