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  1. Article

    Open Access

    High precision in epileptic seizure self-reporting with an app diary

    People with epilepsy frequently under- or inaccurately report their seizures, which poses a challenge for evaluating their treatment. The introduction of epilepsy health apps provides a novel approach that cou...

    Nicolas Zabler, Lauren Swinnen, Andrea Biondi, Yulia Novitskaya in Scientific Reports (2024)

  2. Article

    Open Access

    Addressing data limitations in seizure prediction through transfer learning

    According to the literature, seizure prediction models should be developed following a patient-specific approach. However, seizures are usually very rare events, meaning the number of events that may be used t...

    Fábio Lopes, Mauro F. Pinto, António Dourado, Andreas Schulze-Bonhage in Scientific Reports (2024)

  3. Article

    Open Access

    Erster epileptischer Anfall und Epilepsien im Erwachsenenalter

    In der neuen S2k-Leitlinie „Erster epileptischer Anfall und Epilepsien im Erwachsenenalter“ werden Empfehlungen zu klinisch relevanten Fragestellungen in fünf großen Themenblöcken gegeben: Management erster ep...

    Prof. Dr. Martin Holtkamp, Theodor W. May, Ralf Berkenfeld in Clinical Epileptology (2024)

  4. Article

    Open Access

    Technical note: preliminary surgical experience with a new implantable epicranial stimulation device for chronic focal cortex stimulation in drug-resistant epilepsy

    This study is to report some preliminary surgical considerations and outcomes after the first implantations of a new and commercially available implantable epicranial stimulation device for focal epilepsy.

    Volker A. Coenen, Nadja Jarc, Martin Hirsch, Peter C. Reinacher in Acta Neurochirurgica (2024)

  5. Article

    Open Access

    Ripple-locked coactivity of stimulus-specific neurons and human associative memory

    Associative memory enables the encoding and retrieval of relations between different stimuli. To better understand its neural basis, we investigated whether associative memory involves temporally correlated sp...

    Lukas Kunz, Bernhard P. Staresina, Peter C. Reinacher, Armin Brandt in Nature Neuroscience (2024)

  6. Article

    Open Access

    Dynamic facial emotion recognition and affective prosody recognition are associated in patients with temporal lobe epilepsy

    Deficits in facial emotion recognition have frequently been established in temporal lobe epilepsy (TLE). However, static, rather than dynamic emotion recognition paradigms have been applied. Affective prosody ...

    Birgitta Metternich, Nina Gehrer, Kathrin Wagner in Scientific Reports (2024)

  7. Article

    Efficacy of ictal neurostimulation—English version

    Neurostimulation is an established procedure for the treatment of drug-resistant epilepsies, with results from controlled and uncontrolled clinical trials indicating neuromodulation-mediated efficacy that incr...

    Martin Hirsch, Andreas Schulze-Bonhage in Clinical Epileptology (2023)

  8. Article

    Open Access

    A Prospective Longitudinal Study of the Effects of Eslicarbazepine Acetate Treatment on Bone Density and Metabolism in Patients with Focal-Onset Epilepsy

    Eslicarbazepine acetate (ESL) is a third-generation anti-seizure medication for patients with focal-onset epilepsy. There are known short-term impacts of classic enzyme-inducing drugs on bone health. For oxcar...

    Martin Hirsch, Ilka Immisch, Susanne Knake, Andreas Schulze-Bonhage in CNS Drugs (2023)

  9. Article

    Open Access

    Diagnostic Accuracy of Epilepsy-dedicated MRI with Post-processing

    To evaluate the diagnostic accuracy of epilepsy-dedicated 3 Tesla MRI including post-processing by correlating MRI, histopathology, and postsurgical seizure outcomes.

    Horst Urbach, Christian Scheiwe, Muskesh J. Shah in Clinical Neuroradiology (2023)

  10. Article

    Open Access

    Removing artefacts and periodically retraining improve performance of neural network-based seizure prediction models

    The development of seizure prediction models is often based on long-term scalp electroencephalograms (EEGs) since they capture brain electrical activity, are non-invasive, and come at a relatively low-cost. Ho...

    Fábio Lopes, Adriana Leal, Mauro F. Pinto, António Dourado in Scientific Reports (2023)

  11. Article

    Open Access

    Wirksamkeit der iktalen Neurostimulation

    Die Neurostimulation ist ein etabliertes Verfahren zur Behandlung pharmakoresistenter Epilepsien, wobei Ergebnisse aus kontrollierten und unkontrollierten klinischen Studien auf eine durch Neuromodulation verm...

    Martin Hirsch, Andreas Schulze-Bonhage in Clinical Epileptology (2023)

  12. No Access

    Article

    Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development

    Malformations of cortical development (MCD) are neurological conditions involving focal disruptions of cortical architecture and cellular organization that arise during embryogenesis, largely from somatic mosa...

    Changuk Chung, **aoxu Yang, Taejeong Bae, Keng Ioi Vong, Swapnil Mittal in Nature Genetics (2023)

  13. Article

    Open Access

    Data quality evaluation in wearable monitoring

    Wearable recordings of neurophysiological signals captured from the wrist offer enormous potential for seizure monitoring. Yet, data quality remains one of the most challenging factors that impact data reliabi...

    Sebastian Böttcher, Solveig Vieluf, Elisa Bruno, Boney Joseph in Scientific Reports (2022)

  14. Article

    Open Access

    How to identify insular epilepsy

    Andreas Schulze-Bonhage, Eva Martinez Lizana in Journal of Neurology (2022)

  15. Article

    Open Access

    Ictal semiology of epileptic seizures with insulo-opercular genesis

    Epileptic seizures with insular genesis are often difficult to distinguish from those originating in the temporal lobe due to their complex and variable semiology. Here, we analyzed differentiating characteris...

    Eva Martinez-Lizana, Armin Brandt, Niels A. Foit, Horst Urbach in Journal of Neurology (2022)

  16. Article

    Open Access

    “Within a minute” detection of focal cortical dysplasia

    To evaluate a MRI postprocessing tool for the enhanced and rapid detection of focal cortical dysplasia (FCD).

    Horst Urbach, Marcel Heers, Dirk-Matthias Altenmueller in Neuroradiology (2022)

  17. Article

    Open Access

    Effect of Cannabidiol on Interictal Epileptiform Activity and Sleep Architecture in Children with Intractable Epilepsy: A Prospective Open-Label Study

    Cannabidiol has been shown to be effective in seizure reduction in patients with Dravet syndrome, Lennox–Gastaut syndrome, and tuberous sclerosis. However, very little is known about its potential to reduce in...

    Kerstin A. Klotz, Daniel Grob, Jan Schönberger, Lea Nakamura in CNS Drugs (2021)

  18. Article

    Open Access

    Food intake precipitates seizures in temporal lobe epilepsy

    Various factors have been considered as potential seizure precipitants. We here assessed the temporal association of food intake and seizure occurrence, and characteristics of seizures and epilepsy syndromes i...

    Dalma Tényi, József Janszky, Sára Jeges, Andreas Schulze-Bonhage in Scientific Reports (2021)

  19. Article

    Open Access

    SUDEP kompakt – praxisrelevante Erkenntnisse und Empfehlungen zum plötzlichen, unerwarteten Tod bei Epilepsie

    „Sudden unexpected death in epilepsy“ (SUDEP) ist der plötzliche, unerwartete Tod eines Epilepsiepatienten, der unter „gutartigen“ Umständen und ohne typische Todesursachen auftritt. SUDEP betrifft alle Epilep...

    Univ.-Prof. Dr. med. Rainer Surges MHBA, Stefan Conrad, Hajo M. Hamer in Der Nervenarzt (2021)

  20. Article

    Open Access

    Impfung zur Vorbeugung der COVID-19-Erkrankung sowie Impfpriorisierung bei Epilepsie

    Der Vorstand der Deutschen Gesellschaft für Epileptologie und die Kommission „Epilepsie und Synkopen“ der Deutschen Gesellschaft für Neurologie haben die aktuelle Datenlage zur Impfung zur Vorbeugung der Coron...

    Prof. Dr. Adam Strzelczyk, Susanne Knake, Martin Holtkamp in Zeitschrift für Epileptologie (2021)

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