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Article
Open AccessEventPointer: an effective identification of alternative splicing events using junction arrays
Alternative splicing (AS) is a major source of variability in the transcriptome of eukaryotes. There is an increasing interest in its role in different pathologies. Before sequencing technology appeared, AS wa...
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Article
Open AccessCombined clinical and genomic signatures for the prognosis of early stage non-small cell lung cancer based on gene copy number alterations
The development of a more refined prognostic methodology for early non-small cell lung cancer (NSCLC) is an unmet clinical need. An accurate prognostic tool might help to select patients at early stages for ad...
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Article
Open AccessGetting DNA copy numbers without control samples
The selection of the reference to scale the data in a copy number analysis has paramount importance to achieve accurate estimates. Usually this reference is generated using control samples included in the stud...
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Article
Open AccessImprovements to previous algorithms to predict gene structure and isoform concentrations using Affymetrix Exon arrays
Exon arrays provide a way to measure the expression of different isoforms of genes in an organism. Most of the procedures to deal with these arrays are focused on gene expression or on exon expression. Althoug...