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Open AccessTranslational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR
The Integrated Stress Response (ISR) helps metazoan cells adapt to cellular stress by limiting the availability of initiator methionyl-tRNA for translation. Such limiting conditions paradoxically stimulate the...
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Open AccessArtificially induced MAIT cells inhibit M. bovis BCG but not M. tuberculosis during in vivo pulmonary infection
There is significant interest in targeting MAIT cells with immunostimulatory agents to enhance immune responses. Mycobacterium tuberculosis (M. tb.) is a pervasive respiratory disease that could benefit from trea...
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Open AccessLong-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes
Immune tolerance to allografts has been pursued for decades as an important goal in transplantation. Administration of apoptotic donor splenocytes effectively induces antigen-specific tolerance to allografts i...
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Open AccessIdeal vs. real: a systematic review on handling covariates in randomized controlled trials
In theory, efficient design of randomized controlled trials (RCTs) involves randomization algorithms that control baseline variable imbalance efficiently, and corresponding analysis involves pre-specified adju...
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Obstetric patients’ perspectives on functional magnetic neuroimaging research in pregnant women
Magnetic resonance neuroimaging (MRI) studies of healthy pregnant women could identify key mechanisms of spontaneous health behavior changes observed in expectant mothers as novel intervention targets, but are...
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Open AccessFetal cord blood and tissue immune responses to chronic placental inflammation and chorioamnionitis
Chorioamnionitis is a risk factor for future asthma development. Animal models of chorioamnionitis demonstrate increased TH17-to-Treg ratios associated with proinflammatory cytokine elevations. The association of...
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Open AccessDifferential host gene responses from infection with neurovirulent and partially-neurovirulent strains of Venezuelan equine encephalitis virus
Venezuelan equine encephalitis virus (VEEV) is an alphavirus in the family Togaviridae. VEEV causes a bi-phasic illness in mice where primary replication in lymphoid organs is followed by entry into the central n...
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Open AccessThe transcriptional profile of coronary arteritis in Kawasaki disease
Kawasaki Disease (KD) can cause potentially life-threatening coronary arteritis in young children, and has a likely infectious etiology. Transcriptome profiling is a powerful approach to investigate gene expre...
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Open AccessMetaDiff: differential isoform expression analysis using random-effects meta-regression
RNA sequencing (RNA-Seq) allows an unbiased survey of the entire transcriptome in a high-throughput manner. A major application of RNA-Seq is to detect differential isoform expression across experimental condi...
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Open AccessPhelan-McDermid syndrome: a review of the literature and practice parameters for medical assessment and monitoring
Autism spectrum disorder (ASD) and intellectual disability (ID) can be caused by mutations in a large number of genes. One example is SHANK3 on the terminal end of chromosome 22q. Loss of one functional copy of S...
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Open AccessProspective investigation of autism and genotype-phenotype correlations in 22q13 deletion syndrome and SHANK3 deficiency
22q13 deletion syndrome, also known as Phelan-McDermid syndrome, is a neurodevelopmental disorder characterized by intellectual disability, hypotonia, delayed or absent speech, and autistic features. SHANK3 has b...
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Effect of d-amphetamine on post-error slowing in healthy volunteers
Post-error slowing has long been considered a sign of healthy error detection and an important component of cognitive function. However, the neuropharmacological processes underlying post-error slowing are poo...
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