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Article
Open AccessModeling early germline immunization after horizontal transfer of transposable elements reveals internal piRNA cluster heterogeneity
A fraction of all genomes is composed of transposable elements (TEs) whose mobility needs to be carefully controlled. In gonads, TE activity is repressed by PIWI-interacting RNAs (piRNAs), a class of small RNA...
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Article
Open AccessStructural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration
The yeast Ty1 retrotransposon integrates upstream of genes transcribed by RNA polymerase III (Pol III). Specificity of integration is mediated by an interaction between the Ty1 integrase (IN1) and Pol III, cur...
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Article
Open AccessA proteomic screen of Ty1 integrase partners identifies the protein kinase CK2 as a regulator of Ty1 retrotransposition
Transposable elements are ubiquitous and play a fundamental role in sha** genomes during evolution. Since excessive transposition can be mutagenic, mechanisms exist in the cells to keep these mobile elements...
