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Open AccessA comprehensive review of phytochemicals of Withania somnifera (L.) Dunal (Solanaceae) as antiviral therapeutics
Viruses have caused millions and billions of infections and high mortality rates without successful immunization due to a lack of antiviral drugs approved for clinical use. Therefore, the discovery of novel an...
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Article
Insights into the mechanisms of diabetic wounds: pathophysiology, molecular targets, and treatment strategies through conventional and alternative therapies
Diabetes mellitus is a prevalent cause of mortality worldwide and can lead to several secondary issues, including DWs, which are caused by hyperglycemia, diabetic neuropathy, anemia, and ischemia. Roughly 15% ...
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Article
Open AccessRetraction Note: Antidiabetic, renal/hepatic/pancreas/cardiac protective and antioxidant potential of methanol/dichloromethane extract of Albizzia Lebbeck Benth. Stem bark (ALEx) on streptozotocin induced diabetic rats
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Open AccessRetraction Note: Antidiabetic, antioxidant, antihyperlipidemic effect of extract of Euryale ferox salisb. With enhanced histopathology of pancreas, liver and kidney in streptozotocin induced diabetic rats
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Article
The Backyard Weather Science Curriculum: Using a Weather-Observing Network to Support Data-Intensive Issue-Based Atmospheric Inquiry in Middle and High School
This theoretical article proposes using statewide weather-observing networks (Mesonets) to support data-intensive, issue-based teaching of atmospheric topics in middle and high school science. It is argued tha...
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Retraction Note to: Phytofabricated silver nanoparticles of Phyllanthus emblica attenuated diethylnitrosamine‑induced hepatic cancer via knock‑down oxidative stress and inflammation
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Open AccessRetraction Note: Melastoma malabathricum Linn attenuates complete freund’s adjuvant-induced chronic inflammation in Wistar rats via inflammation response
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12906-016-1470-9.
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Effective Luteinizing Hormone Drug Delivery by Nanocarriers in Hormonal Cancer Treatment
The luteinizing hormone (LH) secretes mainly two types of hormone, that is, LH and follicle-stimulating hormone (FSH). The receptors of luteinizing hormone-releasing hormone (LHRH) are overexpression in the ma...
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Effect of Thymoquinone and its Delivery through Using of Nanomedicine in Benign Prostatic Hyperplasia
Thymoquinone (TQ) is a water-insoluble phytochemical compound (black caraway) isolated from Nigella sativa, which is highly recommended as a carcinogen. The reason for this appearance is the polymeric nanoscal...
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Phytochemistry, Pharmacology, and Applications of Ocimum sanctum (Tulsi)
Ocimum sanctum, an aromatic and medicinal herb, has gained a special importance for its pharmacological potential since time immemorial. The meaning of tulsi in Sanskrit is “Matchless” and called as queen of all ...
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Pancreatic Cancer: Nanoparticle Targeted Therapy Via Epidermal Growth Factor Receptor
Pancreatic cancer is the malignant neoplasm of pancreas and has the worst mortality rate with a 5-year survival rate of only 7%. Pancreatic cancer is tough to detect, hard to diagnose, and early to metastasize...
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Cultural, Practical, and Socio-Economic Importance of Edible Medicinal Plants Native to Central India
The medicinal plants have made a significant contribution to human health from the origin of life. Central India contains a wide variety of medicinal plants, these medicinal plants are used by tribal communiti...
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Polyphenols as Modulators of Oxidative Stress in Cancer Disease
Epidemiologic reports have revealed that cancer is a major health risk and considered a leading cause of increasing death rates all over the world. High oxidative stress can mediate chronic diseases such as on...
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RETRACTED ARTICLE: Phytofabricated silver nanoparticles of Phyllanthus emblica attenuated diethylnitrosamine-induced hepatic cancer via knock-down oxidative stress and inflammation
Oxidative stress and inflammation play a pivotal role in the expansion and progression of hepatic cancer. Nanoparticle-based drug delivery can quickly enhance the restorative capability of hepatic cancer. Sil...
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Article
Molecular Docking and Cognitive Impairment Attenuating Effect of Phenolic Compound Rich Fraction of Trianthema portulacastrum in Scopolamine Induced Alzheimer’s Disease Like Condition
Dementia is considered as the frequent cause of neurodegenerative mental disorder such as Alzheimer’s disease (AD) amongst elderly people. Free radicals as well as cholinergic deficit neurons within nucleus ba...
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Quinazoline clubbed 1,3,5-triazine derivatives as VEGFR2 kinase inhibitors: design, synthesis, docking, in vitro cytotoxicity and in ovo antiangiogenic activity
A series of quinazoline clubbed 1,3,5-triazine derivatives (QCT) were synthesized and evaluated for their in vitro anticancer activity against HeLa (human cervical cancer), MCF-7 (human breast cancer cell), HL...
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Article
Triterpenoids principle of Wedelia calendulacea attenuated diethynitrosamine-induced hepatocellular carcinoma via down-regulating oxidative stress, inflammation and pathology via NF-kB pathway
The aerial part of Wedelia calendulacea have been used in Ayurveda, Unani, Tibetan, Siddha and other folk medicine systems to protect the liver and renal tissue. Liver is considered as primary metabolizing site o...
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Open AccessDesign and discovery of novel monastrol-1,3,5-triazines as potent anti-breast cancer agent via attenuating Epidermal Growth Factor Receptor tyrosine kinase
A novel series of hybrid analogues of monastrol-1,3,5-triazine were designed and developed via one-pot synthesis using Bi(NO3)3 as a catalyst. Entire compounds were evaluated for their anticancer activity against...
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Novel glycoside from Wedelia calendulacea inhibits diethyl nitrosamine-induced renal cancer via downregulating the COX-2 and PEG2 through nuclear factor-κB pathway
A new compound derivative of glycoside 19-α-hydroxy-ursolic acid glucoside (19-α-hydroxyurs-12(13)-ene-28-oic acid-3-O-β-d-glucopyranoside (HEG) was isolated from whole plant of Wedelia calendulacea (Compositae)....
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Article
Open AccessRETRACTED ARTICLE: Melastoma malabathricum Linn attenuates complete freund’s adjuvant-induced chronic inflammation in Wistar rats via inflammation response
Natural products use for arthritis treatment is gaining importance in the medical worldt. Various studies reports medical importance of Melastoma malabathricum Linn. (MM) (Melastomataceae), also known as “putki,”...
