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    PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing

    The sensing of microbial genetic material by leukocytes often elicits beneficial pro-inflammatory cytokines, but dysregulated responses can cause severe pathogenesis. Genome-wide association studies have linke...

    Amanda L. Gavin, Deli Huang, Christoph Huber, Annica Mårtensson… in Nature Immunology (2018)