-
Article
Open AccesspiRNA associates with immune diseases
PIWI-interacting RNA (piRNA) is the most abundant small non-coding RNA in animal cells, typically 26–31 nucleotides in length and it binds with PIWI proteins, a subfamily of Argonaute proteins. Initially disco...
-
Article
Open AccessCirculating miRNAs associate with historical childhood asthma hospitalization in different serum vitamin D groups
Vitamin D may help to alleviate asthma exacerbation because of its anti-inflammation effect, but the evidence is inconsistent in childhood asthma. MiRNAs are important mediators in asthma pathogenesis and also...
-
Article
Open AccessAntagonizing cholecystokinin A receptor in the lung attenuates obesity-induced airway hyperresponsiveness
Obesity increases asthma prevalence and severity. However, the underlying mechanisms are poorly understood, and consequently, therapeutic options for asthma patients with obesity remain limited. Here we report...
-
Article
Open AccessCOMPSRA: a COMprehensive Platform for Small RNA-Seq data Analysis
Small RNA-Seq is a common means to interrogate the small RNA’ome or the full spectrum of small RNAs (<200 nucleotide length) of a biological system. A pivotal problem in NGS based small RNA analysis is identif...
-
Article
Open AccessEpigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age
Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated...
-
Article
Open AccessExpression of SMARCD1 interacts with age in association with asthma control on inhaled corticosteroid therapy
Global gene expression levels are known to be highly dependent upon gross demographic features including age, yet identification of age-related genomic indicators has yet to be comprehensively undertaken in a ...
-
Article
Open AccessMechanical forces induce an asthma gene signature in healthy airway epithelial cells
Bronchospasm compresses the bronchial epithelium, and this compressive stress has been implicated in asthma pathogenesis. However, the molecular mechanisms by which this compressive stress alters pathways rele...
-
Article
Open AccessCirculating microRNAs and prediction of asthma exacerbation in childhood asthma
Circulating microRNAs have shown promise as non-invasive biomarkers and predictors of disease activity. Prior asthma studies using clinical, biochemical and genomic data have not shown excellent prediction of ...
-
Article
Open AccessGene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures
Fragile X syndrome (FXS) is a neurodevelopmental disorder whose biochemical manifestations involve dysregulation of mGluR5-dependent pathways, which are widely modeled using cultured neurons. In vitro phenotyp...
-
Article
Unjamming and cell shape in the asthmatic airway epithelium
From coffee beans flowing in a chute to cells remodelling in a living tissue, a wide variety of close-packed collective systems—both inert and living—have the potential to jam. The collective can sometimes flo...
-
Chapter
Information Processing at the Genomics Level
A central objective in biology is to identify and characterize the mechanistic underpinnings (e.g., gene, protein interactions) of a biological phenomenon (e.g., a phenotype). Today, it is technologically feas...
-
Article
Open AccessVitamin D related genes in lung development and asthma pathogenesis
Poor maternal vitamin D intake is a risk factor for subsequent childhood asthma, suggesting that in utero changes related to vitamin D responsive genes might play a crucial role in later disease susceptibility. W...
-
Article
Open AccessExpression analysis of asthma candidate genes during human and murine lung development
Little is known about the role of most asthma susceptibility genes during human lung development. Genetic determinants for normal lung development are not only important early in life, but also for later lung ...
-
Article
Open AccessPlatform dependence of inference on gene-wise and gene-set involvement in human lung development
With the recent development of microarray technologies, the comparability of gene expression data obtained from different platforms poses an important problem. We evaluated two widely used platforms, Affymetri...
-
Article
Open AccessTranscriptome-scale similarities between mouse and human skeletal muscles with normal and myopathic phenotypes
Mouse and human skeletal muscle transcriptome profiles vary by muscle type, raising the question of which mouse muscle groups have the greatest molecular similarities to human skeletal muscle.
-
Article
The influence of muscle type and dystrophin deficiency on murine expression profiles
The phenotypic differences among Duchenne muscular dystrophy patients, mdx mice, and mdx5cv mice suggest that despite the common etiology of dystrophin deficiency, secondary mechanisms have a substantial influenc...
-
Article
Gene expression profiling of Duchenne muscular dystrophy skeletal muscle
The primary cause of Duchenne muscular dystrophy (DMD) is a mutation in the dystrophin gene, leading to absence of the corresponding protein, disruption of the dystrophin-associated protein complex, and substa...
