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Article
Open AccessLeukemia relapse via genetic immune escape after allogeneic hematopoietic cell transplantation
Graft-versus-leukemia (GvL) reactions are responsible for the effectiveness of allogeneic hematopoietic cell transplantation as a treatment modality for myeloid neoplasia, whereby donor T- effector cells recog...
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Article
Open AccessThe MHC class I MICA gene is a histocompatibility antigen in kidney transplantation
The identity of histocompatibility loci, besides human leukocyte antigen (HLA), remains elusive. The major histocompatibility complex (MHC) class I MICA gene is a candidate histocompatibility locus. Here, we inve...
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Article
Open AccessCynomolgus macaque IL37 polymorphism and control of SIV infection
The association between gene polymorphisms and plasma virus load at the set point (SP-PVL) was investigated in Mauritian macaques inoculated with SIV. Among 44 macaques inoculated with 50 AID50, six individual...
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Article
Open AccessWhole genome sequencing in the search for genes associated with the control of SIV infection in the Mauritian macaque model
In the Mauritian macaque experimentally inoculated with SIV, gene polymorphisms potentially associated with the plasma virus load at a set point, approximately 100 days post inoculation, were investigated. Amo...
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Article
Discovery of novel MHC-class I alleles and haplotypes in Filipino cynomolgus macaques (Macaca fascicularis) by pyrosequencing and Sanger sequencing
Although the low polymorphism of the major histocompatibility complex (MHC) transplantation genes in the Filipino cynomolgus macaque (Macaca fascicularis) is expected to have important implications in the selecti...
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Article
Deleterious impact of feto-maternal MHC compatibility on the success of pregnancy in a macaque model
The impact of feto-maternal histocompatibility on reproduction has inspired long-lasting debates. However, after the review of numerous articles, the impact of HLA allele sharing within couples on fecundity re...
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Article
Study of cynomolgus monkey (Macaca fascicularis) Mhc DRB gene polymorphism in four populations
The cynomolgus macaque (Macaca fascicularis) is currently used as an animal model in various fields of immunology especially in the development of innovative vaccines for the prevention and treatment of infectiou...
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Article
Characterization of MHC class I transcripts of a Malaysian cynomolgus macaque by high-throughput pyrosequencing and EST libraries
We characterized the repertoire of MHC class I transcripts of a Malaysian cynomolgus macaque by the study of EST libraries derived from the mRNA extracted from six tissues (thymus, spleen, bone marrow, liver, ...
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Article
Influence of the MHC genotype on the progression of experimental SIV infection in the Mauritian cynomolgus macaque
Experimental infection of Mauritian cynomolgus macaques by simian immunodeficiency virus is a representative model of HIV infection, currently in favour for evaluating the efficacy of new preventive or curativ...
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Article
Impact of MHC class II polymorphism on blood counts of CD4+ T lymphocytes in macaque
While the number of peripheral blood T lymphocytes and of their two main subsets (CD4+CD8− and CD4−CD8+) varies little in a given healthy individual, substantial variation is observed between individuals. It w...
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Article
Study of cynomolgus monkey (Macaca fascicularis) DRA polymorphism in four populations
To describe the polymorphism of the DRA gene in Macaca fascicularis, we have studied 141 animals either at cDNA level (78 animals from Mauritius, the Philippines, and Vietnam) or genomic level (63 animals from th...
