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MIMAS: microfluidic platform in tandem with MALDI mass spectrometry for protein quantification from small cell ensembles
Understanding cell-to-cell variation at the molecular level provides relevant information about biological phenomena and is critical for clinical and biological research. Proteins carry important information n...
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Open AccessSegmented flow generator for serial crystallography at the European X-ray free electron laser
Serial femtosecond crystallography (SFX) with X-ray free electron lasers (XFELs) allows structure determination of membrane proteins and time-resolved crystallography. Common liquid sample delivery continuousl...
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Manabu Tokeshi (Ed.): Applications of microfluidic systems in biology and medicine
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Open AccessAuthor Correction: Membrane protein megahertz crystallography at the European XFEL
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Time-resolved serial femtosecond crystallography at the European XFEL
The European XFEL (EuXFEL) is a 3.4-km long X-ray source, which produces femtosecond, ultrabrilliant and spatially coherent X-ray pulses at megahertz (MHz) repetition rates. This X-ray source has been designed...
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Open AccessMembrane protein megahertz crystallography at the European XFEL
The world’s first superconducting megahertz repetition rate hard X-ray free-electron laser (XFEL), the European XFEL, began operation in 2017, featuring a unique pulse train structure with 886 ns between pulse...
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Microfluidic sample delivery for serial crystallography using XFELs
Serial femtosecond crystallography (SFX) with X-ray free electron lasers (XFELs) is an emerging field for structural biology. One of its major impacts lies in the ability to reveal the structure of complex pro...
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Small Is Beautiful: Growth and Detection of Nanocrystals
With the advent of X-Ray free electron lasers (FELs), the field of serial femtosecond crystallography (SFX) was borne, allowing a stream of nanocrystals to be measured individually and diffraction data to be c...
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Serial time-resolved crystallography of photosystem II using a femtosecond X-ray laser
Femtosecond X-ray pulses were used to obtain diffraction data on photosystem II, revealing conformational changes as the complex transitions from the dark S1 state to the double-pumped S3 state; the time-resolved...
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Selective trap** of single mammalian breast cancer cells by insulator-based dielectrophoresis
The trap** or immobilization of individual cells at specific locations in microfluidic platforms is essential for single cell studies, especially those requiring cell stimulation and downstream analysis of c...
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Direct detection of peptides and proteins on a microfluidic platform with MALDI mass spectrometry
The ability to detect and quantify proteins of individual cells in high throughput is of enormous biological and clinical relevance. Most methods currently in use either require the measurement of large cell p...
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Ursula Bilitewski (Ed.): Microchip methods in diagnostics
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Steffen Hardt and Friedhelm Schönfeld (Eds.): Microfluidic technologies for miniaturized analysis systems
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Microfluidics in cell analysis
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Systems Nanobiology: From Quantitative Single Molecule Biophysics to Microfluidic-Based Single Cell Analysis
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Absolute negative particle mobility
Noise effects in technological applications, far from being a nuisance, can be exploited with advantage — for example, unavoidable thermal fluctuations have found application in the transport and sorting of co...
