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within Alexander I. Agoulnik Remove this filter Science, Humanities and Social Sciences, multidisciplinary Remove this filter

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  1. Article

    Open Access

    ML290 is a biased allosteric agonist at the relaxin receptor RXFP1

    Activation of the relaxin receptor RXFP1 has been associated with improved survival in acute heart failure. ML290 is a small molecule RXFP1 agonist with simple structure, long half-life and high stability. Her...

    Martina Kocan, Mohsin Sarwar, Sheng Y. Ang, **gbo **ao… in Scientific Reports (2017)

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  2. No Access

    Article

    Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1

    The anti-fibrotic, vasodilatory and pro-angiogenic therapeutic properties of recombinant relaxin peptide hormone have been investigated in several diseases, and recent clinical trial data has shown benefit in ...

    **gbo **ao, Zaohua Huang, Catherine Z. Chen, Irina U. Agoulnik… in Nature Communications (2013)