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  1. Article

    Open Access

    ML290 is a biased allosteric agonist at the relaxin receptor RXFP1

    Activation of the relaxin receptor RXFP1 has been associated with improved survival in acute heart failure. ML290 is a small molecule RXFP1 agonist with simple structure, long half-life and high stability. Her...

    Martina Kocan, Mohsin Sarwar, Sheng Y. Ang, **gbo **ao… in Scientific Reports (2017)

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    Article

    The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4

    The relaxin family peptide receptor 4 (RXFP4) is a G protein-coupled receptor (GPCR) expressed in the colorectum with emerging roles in metabolism and appetite regulation. It is activated by its cognate ligand...

    Sheng Y. Ang, Dana S. Hutchinson… in Naunyn-Schmiedeberg's Archives of Pharmaco… (2017)