8 Result(s)
within
Alexander I. Agoulnik
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Article
Open AccessDiscovery of small molecule agonists of the Relaxin Family Peptide Receptor 2
The relaxin/insulin-like family peptide receptor 2 (RXFP2) belongs to the family of class A G-protein coupled receptors (GPCRs) and it is the only known target for the insulin-like factor 3 peptide (INSL3). Th...
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Article
Open AccessINPP4B protects from metabolic syndrome and associated disorders
A high fat diet and obesity have been linked to the development of metabolic dysfunction and the promotion of multiple cancers. The causative cellular signals are multifactorial and not yet completely understo...
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Article
Open AccessML290 is a biased allosteric agonist at the relaxin receptor RXFP1
Activation of the relaxin receptor RXFP1 has been associated with improved survival in acute heart failure. ML290 is a small molecule RXFP1 agonist with simple structure, long half-life and high stability. Her...
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Article
Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1
The anti-fibrotic, vasodilatory and pro-angiogenic therapeutic properties of recombinant relaxin peptide hormone have been investigated in several diseases, and recent clinical trial data has shown benefit in ...
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Protocol
Spermatogenesis in Cryptorchidism
Cryptorchidism or undescended testis is the most frequent congenital abnormality in newborn boys. The process of testicular descent to the scrotum is controlled by hormones produced in Leydig cells, insulin-li...
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Article
A missense mutation in LRR8 of RXFP2 is associated with cryptorchidism
Using genome-wide mutagenesis with N-ethyl-N-nitrosourea (ENU), a mouse mutant with cryptorchidism was identified. Genome map** and exon sequencing identified a novel missense mutation (D294G) in Relaxin/insuli...
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Chapter
Relaxin and Related Peptides in Male Reproduction
The relaxin hormone is renowned for its function in pregnancy, parturition and other aspects of female reproduction. At the same time, the role of relaxin in male reproduction is still debated. Relaxin is prom...
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Article
A transgenic insertion upstream of Sox9 is associated with dominant XX sex reversal in the mouse
In most mammals, male development is triggered by the transient expression of the Y-chromosome gene, Sry, which initiates a cascade of gene interactions ultimately leading to the formation of a testis from the in...
