13 Result(s)
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Alessandra Salvetti
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Article
Repeated DNA elements in planarians of the Dugesia gonocephala group (Platyhelminthes, Tricladida)
The results of the isolation of repetitive DNA elements in the genome of Dugesia etrusca, a species of the Dugesia gonocephala group, are reported. These sequences, about 1.4 kb long, represent only a part of ...
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Article
DjPiwi-1, a member of the PAZ-Piwi gene family, defines a subpopulation of planarian stem cells
Planarian regeneration, based upon totipotent stem cells, the neoblasts, provides a unique opportunity to study in vivo the molecular program that defines a stem cell. In this study, we report the identificati...
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Open AccessDeciphering the molecular machinery of stem cells: a look at the neoblast gene expression profile
Mammalian stem cells are difficult to access experimentally; model systems that can regenerate offer an alternative way to characterize stem cell related genes. Planarian regeneration depends on adult pluripot...
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Open AccessDrugs targeting the mitochondrial pore act as citotoxic and cytostatic agents in temozolomide-resistant glioma cells
High grade gliomas are one of the most difficult cancers to treat and despite surgery, radiotherapy and temozolomide-based chemotherapy, the prognosis of glioma patients is poor. Resistance to temozolomide is ...
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Open AccessCapsid protein expression and adeno-associated virus like particles assembly in Saccharomyces cerevisiae
The budding yeast Saccharomyces cerevisiae supports replication of many different RNA or DNA viruses (e.g. Tombusviruses or Papillomaviruses) and has provided means for up-scalable, cost- and time-effective produ...
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Prohibitin 2 Regulates Cell Proliferation and Mitochondrial Cristae Morphogenesis in Planarian Stem Cells
Prohibitins are pleiotropic proteins, whose multiple roles are emerging as key elements in the regulation of cell survival and proliferation. Indeed, prohibitins interact with several intracellular proteins st...
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Open AccessChlorophyll derivatives enhance invertebrate red-light and ultraviolet phototaxis
Chlorophyll derivatives are known to enhance vision in vertebrates. They are thought to bind visual pigments (i.e., opsins apoproteins bound to retinal chromophores) directly within the retina. Consistent with pr...
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Article
Open AccessPutrescine independent wound response phenotype is produced by ODC-like RNAi in planarians
Despite increasing evidence indicates polyamines as a convergence point for signaling pathways, including cell growth and differentiation, a unifying concept to interpret their role is still missing. The activ...
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Development of a yeast-based system to identify new hBRAFV600E functional interactors
BRAFV600E is a mutant Ser–Thr protein kinase that plays a crucial role in many types of cancer, including melanoma. Despite several aspects of BRAFV600E biology have been already elucidated, the proteins that ...
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Open AccessAntitumoral effects of attenuated Listeria monocytogenes in a genetically engineered mouse model of melanoma
Attenuated Listeria monocytogenes (Lmat-LLO) represents a valuable anticancer vaccine and drug delivery platform. Here we show that in vitro Lmat-LLO causes ROS production and, in turn, apoptotic killing of a wid...
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Open AccessHow do gravity alterations affect animal and human systems at a cellular/tissue level?
The present white paper concerns the indications and recommendations of the SciSpacE Science Community to make progress in filling the gaps of knowledge that prevent us from answering the question: “How Do Gra...
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Open AccessHow are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?
Progress in mechanobiology allowed us to better understand the important role of mechanical forces in the regulation of biological processes. Space research in the field of life sciences clearly showed that gr...
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Open AccessHow to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?
Periodically, the European Space Agency (ESA) updates scientific roadmaps in consultation with the scientific community. The ESA SciSpacE Science Community White Paper (SSCWP) 9, “Biology in Space and Analogue...
