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Article
In Vivo Murine Models of Cardiotoxicity Due to Anticancer Drugs: Challenges and Opportunities for Clinical Translation
Modern therapeutic approaches have led to an improvement in the chances of surviving a diagnosis of cancer. However, this may come with side effects, with patients experiencing adverse cardiovascular events or...
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Article
Silencing Survivin: a Key Therapeutic Strategy for Cardiac Hypertrophy
Cardiac hypertrophy, in its aspects of localized thickening of the interventricular septum and concentric increase of the left ventricle, constitutes a risk factor of heart failure. Myocardial hypertrophy, in ...
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Article
Modification of cardiac thyroid hormone deiodinases expression in an ischemia/reperfusion rat model after T3 infusion
The deiodinases regulate the activation and inactivation of Thyroid hormones (TH), in both physiological and pathological conditions. The three deiodinases, DIO1, DIO2 and DIO3, have different catalytic role a...
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Article
Murine model of left ventricular diastolic dysfunction and electro-mechanical uncoupling following high-fat diet
It is well established that obesity is an independent risk factor for cardiac death. In particular various cardiac alterations have been described in obese patients such as long QT on ECG, impaired diastolic f...
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TH Metabolism in Ischemia/Reperfusion Models
Clinical evidence has shown that the two major outcomes of thyroid disease, namely, hypothyroidism and hyperthyroidism, cause evident alterations in haemodynamics and cardiac function. Moreover, even subclinic...
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Article
Spatial Inhomogeneity of Cardiac Norepinephrine Transport Protein and Meta-[123I]Iodobenzylguanidine Uptake in Swine Myocardial Tissue
The aim of the present study was to evaluate the expression of the cardiac norepinephrine transporter (NET) in the left ventricle (LV) of healthy pigs and its relationship with regional meta-[123I]iodobenzylguani...
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Article
Open AccessAntitumoral effects of attenuated Listeria monocytogenes in a genetically engineered mouse model of melanoma
Attenuated Listeria monocytogenes (Lmat-LLO) represents a valuable anticancer vaccine and drug delivery platform. Here we show that in vitro Lmat-LLO causes ROS production and, in turn, apoptotic killing of a wid...
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Article
Modification of gene expression profiling related to renin–angiotensin system in an ischemia/reperfusion rat model after T3 infusion
Triiodothyronine (T3) and renin–angiotensin system (RAS) are functionally related in cardiovascular system. Recently, in an in vivo myocardial ischemia/reperfusion (I/R) model in rats, we showed that T3 treatm...
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Article
Open AccessP54 A Machine Learning System for Carotid Plaque Vulnerability Assessment Based on Ultrasound Images
Carotid plaque vulnerability assessment is essential for the identification of high-risk patients. A specific mouse model for the study of carotid atherosclerosis has been recently developed. Aim of this study...
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Article
Open AccessIntegrative analysis of differentially expressed genes and miRNAs predicts complex T3-mediated protective circuits in a rat model of cardiac ischemia reperfusion
Thyroid hormone (T3) dyshomeostasis in the cardiac ischemia-reperfusion (IR) setting negatively impacts on mitochondria function and extracellular matrix remodeling. The modulation of cardiac miRNAs may repres...
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Article
Open AccessP78: Longitudinal Micro-Ultrasound assessment of the OB/OB Mouse Model: Evaluation of Cardiovascular, Renal and Hepatic Parameters
Obesity is associated with increased risk factors for cardiovascular disease (CVD). Leptin-deficient mice (ob/ob) are widely employed to investigate obesity. This study is aimed at providing a micro-ultrasound (m...
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Article
Open AccessP79: Ultrasonographic Characterization of the DB/DB Mouse, An Animal Model of Metabolic Abnormalities
The availability of an animal model that, beside common blood parameters like hyperglycemia or high lipid levels, reliably mirrors organ damage occurring in metabolic diseases, is an urgent need. These animals...
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Article
Wave intensity analysis in mice: age-related changes in WIA peaks and correlation with cardiac indexes
Mouse models are increasingly employed in the comprehension of cardiovascular disease. Wave Intensity Analysis (WIA) can provide information about the interaction between the vascular and the cardiac system. W...
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Article
Cardioprotection and thyroid hormones
The evolution of cardiac disease after an acute ischemic event depends on a complex and dynamic network of mechanisms alternating from ischemic damage due to acute coronary occlusion to reperfusion injury due ...
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Article
Open AccessP4.21 Microcirculation Effects of Obesity and/or Diet: A Preliminary Study in Mice
Obesity is becoming a global epidemic and is associated with cardiovascular disease. Genetic factors play a significant role in the disease etiology but less is known about the interaction between genes and di...
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Article
Thyroid hormone deiodinases D1, D2, and D3 are expressed in human endothelial dermal microvascular line: effects of thyroid hormones
Endothelial system acts as a large endocrine organ in the human body; however, little is still known about the regulative role of THs on endothelial cells. Aim of the present study was to investigate the expre...
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Article
Open AccessEarly and Short-term Triiodothyronine Supplementation Prevents Adverse Postischemic Cardiac Remodeling: Role of Transforming Growth Factor-β1 and Antifibrotic miRNA Signaling
Activation of transforming growth factor (TGF)-β1 signaling in the ischemia/reperfusion (I/R) injured myocardium leads to dysregulation of miR-29-30-133, favoring the profibrotic process that leads to adverse ...
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Article
Open AccessUp-regulation of heme oxygenase-1 after infarct initiation reduces mortality, infarct size and left ventricular remodeling: experimental evidence and proof of concept
Up-regulation of HO-1 by genetic manipulation or pharmacological pre-treatment has been reported to provide benefits in several animal models of myocardial infarction (MI). However, its efficacy following MI i...
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Article
MicroPET/CT imaging of αvβ3 integrin via a novel 68Ga-NOTA-RGD peptidomimetic conjugate in rat myocardial infarction
The αvβ3 integrin is expressed in angiogenic vessels and is a potential target for molecular imaging of evolving pathological processes. Its expression is upregulated in cancer lesions and metastases as well as i...
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Article
Open AccessSelection of reference genes in different myocardial regions of an in vivo ischemia/reperfusion rat model for normalization of antioxidant gene expression
Changes in cardiac gene expression due to myocardial injury are usually assessed in whole heart tissue. However, as the heart is a heterogeneous system, spatial and temporal heterogeneity is expected in gene e...
