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Chapter and Conference Paper
Name management and object technology for advanced software
Name management is so fundamental to every aspect of computing that it is frequently overlooked or taken for granted. Our research is aimed at develo** both models to improve understanding and mechanisms to imp...
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Chapter and Conference Paper
Conch: Experimenting with Enhanced Name Management for Persistent Object Systems
The name management capabilities currently provided by most existing persistent object systems (POSs) are rather limited. In particular, existing POSs tend to lack powerful and general mechanisms for forming, ...
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Article
Thymidine kinase gene therapy with concomitant topotecan chemotherapy for recurrent ovarian cancer
Introduction: Patients with recurrent ovarian cancer were treated with a replication-deficient recombinant adenovirus containing the herpes simplex virus thymidine kinase gene administered intraperitoneally (i.p....
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Chapter and Conference Paper
Toward Pure Polylingual Persistence
A heterogeneous persistent object system provides multiple programming language interfaces. This gives rise to the polylingual interoperability problem, namely, how can an application uniformly process data ob...
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Article
Toward Automated Support for Transparent Interoperable Queries
Many Object-Oriented Databases (OODBs) use programming languages that predate Java, such as C++, CLOS and Smalltalk. Thus, there is a growing need for interoperating these OODBs with new applications that requ...
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Article
Open AccessCan asthma control be improved by understanding the patient's perspective?
Clinical trials show that asthma can be controlled in the majority of patients, but poorly controlled asthma still imposes a considerable burden. The level of asthma control achieved reflects the behaviour of ...
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Article
Open AccessCanadian clinical practice guidelines for acute and chronic rhinosinusitis
This document provides healthcare practitioners with information regarding the management of acute rhinosinusitis (ARS) and chronic rhinosinusitis (CRS) to enable them to better meet the needs of this patient ...
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Article
Open AccessChronic obstructive pulmonary disease and exacerbations: Patient insights from the global Hidden Depths of COPD survey
Although chronic obstructive pulmonary disease (COPD) is a major global health burden there is a lack of patient awareness of disease severity, particularly in relation to exacerbations.
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Article
Open AccessIs there a rationale and role for long-acting anticholinergic bronchodilators in asthma?
Despite current guidelines and the range of available treatments, over a half of patients with asthma continue to suffer from poor symptomatic control and remain at risk of future worsening. Although a number ...
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Article
Open AccessQuality of asthma care under different primary care models in Canada: a population-based study
Previous research has shown variations in quality of care and patient outcomes under different primary care models. The objective of this study was to use previously validated, evidence-based performance indic...
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Article
Open AccessA systematic review of comparative studies of tiotropium Respimat® and tiotropium HandiHaler® in patients with chronic obstructive pulmonary disease: does inhaler choice matter?
In many countries worldwide, the long-acting anticholinergic drug tiotropium is available as a dry powder formulation delivered by means of the HandiHaler® inhalation device and as an aqueous solution delivere...
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Article
Open AccessCohort Analysis of Exacerbation Rates in Adolescent and Adult Patients Initiating Inhaled Corticosteroids for Asthma: Different Dose–Response Profile by Particle Size
Targeting small airway inflammation could lead to improved clinical outcomes in asthma. Previous observational studies concluded that therapy with extrafine-particle [mass median aerodynamic diameter (MMAD) <...
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Article
Open AccessSolving the mystery of the yellow zone of the asthma action plan
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Article
Open AccessA multi-stakeholder perspective on asthma care in Canada: findings from a mixed methods needs assessment in the treatment and management of asthma in adults
Although several aspects of asthma care have been identified as being sub-optimal in Canada, such as patient education, practice guideline adoption, and access to care, there remains a need to determine the ex...
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Article
Open AccessA comparison of tiotropium, long-acting β2-agonists and leukotriene receptor antagonists on lung function and exacerbations in paediatric patients with asthma
Diagnosing and treating asthma in paediatric patients remains challenging, with many children and adolescents remaining uncontrolled despite treatment. Selecting the most appropriate pharmacological treatment ...
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Article
Open AccessImpact of comorbid conditions on asthmatic adults and children
Comorbid conditions (comorbidities) can complicate the diagnosis and management of asthma. In different age groups, comorbid conditions can present varying challenges, including diagnostic confusion due to mim...
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Article
Open AccessComparing LAMA with LABA and LTRA as add-on therapies in primary care asthma management
The Global Initiative for Asthma recommends a stepwise approach to adjust asthma treatment to the needs of individual patients; inhaled corticosteroids (ICS) remain the core pharmacological treatment. However,...
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Article
Open AccessSwitching Inhalers: A Practical Approach to Keep on UR RADAR
The choice of an inhaler device is often as important as the medication put in it to achieve optimal outcomes for our patients with asthma and/or COPD. With a multitude of drug–device combinations available, o...
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Article
Open AccessA call to action for improving clinical outcomes in patients with asthma
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Article
Open AccessThe Myth of Mild: Severe Exacerbations in Mild Asthma: An Underappreciated, but Preventable Problem
Asthma is a common, chronic inflammatory airway disease, characterised by unpredictable episodes of worsening symptoms, or exacerbations. Causes of asthma exacerbations include viral infections, exposure to al...