54 Result(s)

Article

Midregional Proatrial Natriuretic Peptide (MRproANP) is associated with vertebral fractures and low bone density in patients with chronic obstructive pulmonary disease (COPD)

Patients with COPD are often affected by loss of bone mineral density (BMD) and osteoporotic fractures. Natriuretic peptides (NP) are known as cardiac markers, but have also been linked to fragility-associated...

Franziska C. Trudzinski, Rudolf A. Jörres, Peter Alter, Henrik Watz… in Respiratory Research (2024)

Article

Effects of triple therapy on disease burden in patients of GOLD groups C and D: results from the observational COPD cohort COSYCONET

Randomized controlled trials described beneficial effects of inhaled triple therapy (LABA/LAMA/ICS) in patients with chronic obstructive pulmonary disease (COPD) and high risk of exacerbations. We studied whet...

Jennifer A. Zader, Rudolf A. Jörres, Imke Mayer, Peter Alter… in BMC Pulmonary Medicine (2024)

Article

An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma

Asthma is stratified into type 2-high and type 2-low inflammatory phenotypes. Limited success has been achieved in develo** drugs that target type 2-low inflammation. Previous studies have linked IL-6 signal...

Zaid W. El-Husseini, Dmitry Khalenkow, Andy Lan, Thys van der Molen… in Respiratory Research (2023)

Article

The microbial composition of larval airways from Drosophila melanogaster differ between specimens from laboratory and natural habitats

The fruit fly Drosophila melanogaster lives in natural habitats and has also long been used as a model organism in biological research. In this study, we used a molecular barcoding approach to analyse the airways...

Hanna Angstmann, Stefan Pfeiffer, Susanne Kublik… in Environmental Microbiome (2023)

Article

Cardiovascular predictors of mortality and exacerbations in patients with COPD

In chronic obstructive pulmonary disease (COPD), comorbidities and worse functional status predict worse outcomes, but how these predictors compare with regard to different outcomes is not well studied. We thu...

Peter Alter, Tanja Lucke, Henrik Watz, Stefan Andreas… in Scientific Reports (2022)

Article

A blood-based miRNA signature with prognostic value for overall survival in advanced stage non-small cell lung cancer treated with immunotherapy

Immunotherapies have recently gained traction as highly effective therapies in a subset of late-stage cancers. Unfortunately, only a minority of patients experience the remarkable benefits of immunotherapies, ...

Timothy Rajakumar, Rastislav Horos, Julia Jehn, Judith Schenz… in npj Precision Oncology (2022)

Article

Correction to: Key summary of German national treatment guidance for hospitalized COVID‑19 patients

Jakob J. Malin, Christoph D. Spinner, Uwe Janssens, Tobias Welte… in Infection (2022)

Article

Key summary of German national treatment guidance for hospitalized COVID-19 patients

This executive summary of a national living guideline aims to provide rapid evidence based recommendations on the role of drug interventions in the treatment of hospitalized patients with COVID-19.

Jakob J. Malin, Christoph D. Spinner, Uwe Janssens, Tobias Welte… in Infection (2022)

Article

Impact of imposed social isolation and use of face masks on asthma course and mental health in pediatric and adult patients with recurrent wheeze and asthma

There is currently a dramatic increase in the number of COVID-19 cases worldwide, and further drastic restrictions in our daily life will be necessary to contain this pandemic. The implications of restrictive ...

Nicole Maison, Heidrun Herbrüggen, Bianca Schaub… in Allergy, Asthma & Clinical Immunology (2021)

Article

Raised sputum extracellular DNA confers lung function impairment and poor symptom control in an exacerbation-susceptible phenotype of neutrophilic asthma

Extracellular DNA (e-DNA) and neutrophil extracellular traps (NETs) are linked to asthmatics airway inflammation. However, data demonstrating the characterization of airway inflammation associated with excessi...

Mustafa Abdo, Mohib Uddin, Torsten Goldmann, Sebastian Marwitz… in Respiratory Research (2021)

Article

Sex dependent effect of maternal e-nicotine on F1 Drosophila development and airways

E-cigarettes are heavily advertised as healthier alternative to common tobacco cigarettes, leading more and more women to switch from regular cigarettes to ENDS (electronic nicotine delivery system) during pre...

Natalia El-Merhie, Arne Krüger, Karin Uliczka, Stephanie Papenmeier… in Scientific Reports (2021)

Article

DNA methylation profiles of bronchoscopic biopsies for the diagnosis of lung cancer

Lung cancer is the leading cause of cancer-related death in most western countries in both, males and females, accounting for roughly 20–25% of all cancer deaths. For choosing the most appropriate therapy regi...

Torsten Goldmann, Bernhard Schmitt, Julia Müller, Maren Kröger… in Clinical Epigenetics (2021)

Article

Tiotropium/Olodaterol Delays Clinically Important Deterioration Compared with Tiotropium Monotherapy in Patients with Early COPD: a Post Hoc Analysis of the TONADO^® Trials

Since chronic obstructive pulmonary disease (COPD) is a heterogeneous condition, a composite endpoint of clinically important deterioration (CID) may provide a more holistic assessment of treatment efficacy. W...

Klaus F. Rabe, James D. Chalmers, Marc Miravitlles… in Advances in Therapy (2021)

Article

Small airway dysfunction as predictor and marker for clinical response to biological therapy in severe eosinophilic asthma: a longitudinal observational study

Anti-T2 biological therapies have proven to effectively reduce acute exacerbations and daily doses of oral steroids in severe eosinophilic asthma. Despite the remarkable clinical efficacy, there are usually on...

Mustafa Abdo, Henrik Watz, Vera Veith, Anne-Marie Kirsten… in Respiratory Research (2020)

Article

Exploration of the sputum methylome and omics deconvolution by quadratic programming in molecular profiling of asthma and COPD: the road to sputum omics 2.0

To date, most studies involving high-throughput analyses of sputum in asthma and COPD have focused on identifying transcriptomic signatures of disease. No whole-genome methylation analysis of sputum cells has ...

Espen E. Groth, Melanie Weber, Thomas Bahmer, Frauke Pedersen… in Respiratory Research (2020)

Article

Composite endpoints in COPD: clinically important deterioration in the UPLIFT trial

Assessments of lung function, exacerbations and health status are common measures of chronic obstructive pulmonary disease (COPD) progression and treatment response in clinical trials. We hypothesised that a c...

Klaus F. Rabe, David M. G. Halpin, MeiLan K. Han, Marc Miravitlles… in Respiratory Research (2020)

Article

Benefits of glycopyrrolate/formoterol fumarate metered dose inhaler (GFF MDI) in improving lung function and reducing exacerbations in patients with moderate-to-very severe COPD: a pooled analysis of the PINNACLE studies

The Phase III PINNACLE studies assessed the efficacy and safety of glycopyrrolate/formoterol fumarate metered dose inhaler (GFF MDI), a dual long-acting bronchodilator for chronic obstructive pulmonary disease...

Fernando J. Martinez, Brian J. Lipworth, Klaus F. Rabe… in Respiratory Research (2020)

Article

Live and let die: epigenetic modifications of Survivin and Regucalcin in non-small cell lung cancer tissues contribute to malignancy

Recently, it was shown that the epigenetic age of non-small cell lung cancer (NSCLC) tissues is different from the chronological age of patients. Here, we demonstrate that Regucalcin and Survivin, molecules wh...

Dörte Nitschkowski, Sebastian Marwitz, Sousana A. Kotanidou… in Clinical Epigenetics (2019)

Article

Effects of airway obstruction and hyperinflation on electrocardiographic axes in COPD

COPD influences cardiac function and morphology. Changes of the electrical heart axes have been largely attributed to a supposed increased right heart load in the past, whereas a potential involvement of the l...

Peter Alter, Henrik Watz, Kathrin Kahnert, Klaus F. Rabe… in Respiratory Research (2019)