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Open AccessNeurotransmission-related gene expression in the frontal pole is altered in subjects with bipolar disorder and schizophrenia
The frontal pole (Brodmann area 10, BA10) is the largest cytoarchitectonic region of the human cortex, performing complex integrative functions. BA10 undergoes intensive adolescent grey matter pruning prior to...
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Open AccessMitochondria DNA copy number, mitochondria DNA total somatic deletions, Complex I activity, synapse number, and synaptic mitochondria number are altered in schizophrenia and bipolar disorder
Mitochondrial dysfunction is a neurobiological phenomenon implicated in the pathophysiology of schizophrenia and bipolar disorder that can synergistically affect synaptic neurotransmission. We hypothesized tha...
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Open AccessIdentification of potential blood biomarkers associated with suicide in major depressive disorder
Suicides have increased to over 48,000 deaths yearly in the United States. Major depressive disorder (MDD) is the most common diagnosis among suicides, and identifying those at the highest risk for suicide is ...
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Open AccessA Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials
Criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD) as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the present document we used a Delph...
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Unraveling the opioid actions of S-ketamine and R-ketamine: comment on Bonaventura et al.
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Open AccessDecoding the temporal nature of brain GR activity in the NFκB signal transition leading to depressive-like behavior
The fine-tuning of neuroinflammation is crucial for brain homeostasis as well as its immune response. The transcription factor, nuclear factor-κ-B (NFκB) is a key inflammatory player that is antagonized via an...
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Correction: Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD)
Supplementary Figure 1 and Supplementary Tables 1–4 have been re-uploaded so as to reflect the versions supplied during proofs stage. The publisher apologizes for the error in versioning. The HTML version of t...
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Open AccessDouble-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD)
Numerous placebo-controlled studies have demonstrated the ability of ketamine, an NMDA receptor antagonist, to induce rapid (within hours), transient antidepressant effects when administered intravenously (IV)...
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In Memoriam of George Gardos, MD
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Open AccessNonlinear relationship between early life stress exposure and subsequent resilience in monkeys
Retrospective correlational studies of humans suggest that moderate but not minimal or substantial early life stress exposure promotes the development of stress inoculation-induced resilience. Here we test for...
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Open AccessPrefrontal networks dynamically related to recovery from major depressive disorder: a longitudinal pharmacological fMRI study
Due to lacking predictors of depression recovery, successful treatment of major depressive disorder (MDD) is frequently only achieved after therapeutic optimization leading to a prolonged suffering of patients...
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Open AccessCorticotropin-releasing factor 1 receptor haplotype and cognitive features of major depression
Corticotropin-releasing factor signaling through CRF receptor type 1 (CRF1) has been shown to contribute to learning and memory function. A haplotype of alleles T-A-T in a set of common polymorphisms in the gene ...
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Open AccessStress amplifies sex differences in primate prefrontal profiles of gene expression
Stress is a recognized risk factor for mood and anxiety disorders that occur more often in women than men. Prefrontal brain regions mediate stress co**, cognitive control, and emotion. Here, we investigate s...
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Open AccessPost-mortem molecular profiling of three psychiatric disorders
Psychiatric disorders are multigenic diseases with complex etiology that contribute significantly to human morbidity and mortality. Although clinically distinct, several disorders share many symptoms, suggesti...
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Erratum: Resting-state connectivity biomarkers define neurophysiological subtypes of depression
Nat. Med.; 10.1038/nm.4246; corrected online 19 December 2016 In the version of this article initially published online, the abstract contained two typos reading, “Like to other neuropsychiatric disorders,...”...
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Eberhard H Uhlenhuth
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Open AccessDevelo** a clinical translational neuroscience taxonomy for anxiety and mood disorder: protocol for the baseline-follow up Research domain criteria Anxiety and Depression (“RAD”) project
Understanding how brain circuit dysfunctions relate to specific symptoms offers promise for develo** a brain-based taxonomy for classifying psychopathology, identifying targets for mechanistic studies and ul...
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A Cognitive–Emotional Biomarker for Predicting Remission with Antidepressant Medications: A Report from the iSPOT-D Trial
Depression involves impairments in a range of cognitive and emotional capacities. It is unknown whether these functions can inform medication choice when considered as a composite predictive biomarker. We test...
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Erratum: Ketamine: Promising Path or False Prophecy in the Development of Novel Therapeutics for Mood Disorders?
Correction to: Neuropsychopharmacology (2015) 40, 259–267; doi:10.1038/npp.2014.261; published online 22 October 2014 On page 262 (first paragraph under ‘Ketamine’s Abuse Liability: Mu Opioid Receptor Effects’...
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Decreased Hypothalamic Functional Connectivity with Subgenual Cortex in Psychotic Major Depression
Hypothalamus communication with the rest of the brain and peripheral target tissues is critically important for many physiological and psychological functions. These functions include maintaining neuroendocrin...
