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Article
The why, when, where, how, and so what of so-called rapidly acting antidepressants
Develo** antidepressants that are not only more effective but are rapidly acting is the Holy Grail for psychiatry. We review multiple issues that arise in determining rapid responses in antidepressant trials...
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Article
Randomized trial of ketamine masked by surgical anesthesia in patients with depression
Ketamine may have antidepressant properties, but its acute psychoactive effects complicate successful masking in placebo-controlled trials. Here we present a single-center, parallel-arm, triple-masked, randomi...
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Article
Open AccessNeurotransmission-related gene expression in the frontal pole is altered in subjects with bipolar disorder and schizophrenia
The frontal pole (Brodmann area 10, BA10) is the largest cytoarchitectonic region of the human cortex, performing complex integrative functions. BA10 undergoes intensive adolescent grey matter pruning prior to...
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Article
Open AccessMitochondria DNA copy number, mitochondria DNA total somatic deletions, Complex I activity, synapse number, and synaptic mitochondria number are altered in schizophrenia and bipolar disorder
Mitochondrial dysfunction is a neurobiological phenomenon implicated in the pathophysiology of schizophrenia and bipolar disorder that can synergistically affect synaptic neurotransmission. We hypothesized tha...
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Article
Open AccessIdentification of potential blood biomarkers associated with suicide in major depressive disorder
Suicides have increased to over 48,000 deaths yearly in the United States. Major depressive disorder (MDD) is the most common diagnosis among suicides, and identifying those at the highest risk for suicide is ...
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Article
Open AccessA Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials
Criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD) as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the present document we used a Delph...
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Reference Work Entry In depth
Suicide and Psychotic Depression
Major depression is a debilitating disorder characterized by low mood, anhedonia, hopelessness, sleep disturbances, weight loss/gain, and potentially self-harming behavior. An individual that suffers from psyc...
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Article
Unraveling the opioid actions of S-ketamine and R-ketamine: comment on Bonaventura et al.
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Article
Open AccessDecoding the temporal nature of brain GR activity in the NFκB signal transition leading to depressive-like behavior
The fine-tuning of neuroinflammation is crucial for brain homeostasis as well as its immune response. The transcription factor, nuclear factor-κ-B (NFκB) is a key inflammatory player that is antagonized via an...
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Article
Long-term effects of intermittent early life stress on primate prefrontal–subcortical functional connectivity
Correlational studies of humans suggest that exposure to early life stress has long-term effects on neural circuits involved in vulnerability and resilience to mental health disorders. Stress-related mental he...
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Article
Intrinsic reward circuit connectivity profiles underlying symptom and quality of life outcomes following antidepressant medication: a report from the iSPOT-D trial
There is a critical need to better understand the neural basis of antidepressant medication (ADM) response with respect to both symptom alleviation and quality of life (QoL) in major depressive disorder (MDD)....
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Living Reference Work Entry In depth
Suicide and Psychotic Depression
Major depression is a debilitating disorder characterized by low mood, anhedonia, hopelessness, sleep disturbances, weight loss/gain, and potentially self-harming behavior. An individual that suffers from psyc...
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Article
Correction: Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD)
Supplementary Figure 1 and Supplementary Tables 1–4 have been re-uploaded so as to reflect the versions supplied during proofs stage. The publisher apologizes for the error in versioning. The HTML version of t...
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Article
Open AccessDouble-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD)
Numerous placebo-controlled studies have demonstrated the ability of ketamine, an NMDA receptor antagonist, to induce rapid (within hours), transient antidepressant effects when administered intravenously (IV)...
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Article
In Memoriam of George Gardos, MD
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Article
Attenuation of antidepressant and antisuicidal effects of ketamine by opioid receptor antagonism
We recently reported that naltrexone blocks antidepressant effects of ketamine in humans, indicating that antidepressant effects of ketamine require opioid receptor activation. However, it is unknown if opioid...
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Article
Open AccessNonlinear relationship between early life stress exposure and subsequent resilience in monkeys
Retrospective correlational studies of humans suggest that moderate but not minimal or substantial early life stress exposure promotes the development of stress inoculation-induced resilience. Here we test for...
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Article
Genome-wide association study identifies 30 loci associated with bipolar disorder
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 v...
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Article
Open AccessPrefrontal networks dynamically related to recovery from major depressive disorder: a longitudinal pharmacological fMRI study
Due to lacking predictors of depression recovery, successful treatment of major depressive disorder (MDD) is frequently only achieved after therapeutic optimization leading to a prolonged suffering of patients...
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Article
Neural cell adhesion molecule peptide mimetics modulate emotionality: pharmacokinetic and behavioral studies in rats and non-human primates
Recent evidence highlights the fibroblast growth factor (FGF) family in emotion modulation. Although ligands that activate FGF receptors have antidepressant and anxiolytic effects in animal models, FGF ligands...