25 Result(s)

Article

Neurotransmission-related gene expression in the frontal pole is altered in subjects with bipolar disorder and schizophrenia

The frontal pole (Brodmann area 10, BA10) is the largest cytoarchitectonic region of the human cortex, performing complex integrative functions. BA10 undergoes intensive adolescent grey matter pruning prior to...

Adriana M. Medina, Megan Hastings Hagenauer, David M. Krolewski… in Translational Psychiatry (2023)

Article

Mitochondria DNA copy number, mitochondria DNA total somatic deletions, Complex I activity, synapse number, and synaptic mitochondria number are altered in schizophrenia and bipolar disorder

Mitochondrial dysfunction is a neurobiological phenomenon implicated in the pathophysiology of schizophrenia and bipolar disorder that can synergistically affect synaptic neurotransmission. We hypothesized tha...

Sujan C. Das, Brooke E. Hjelm, Brandi L. Rollins… in Translational Psychiatry (2022)

Article

Identification of potential blood biomarkers associated with suicide in major depressive disorder

Suicides have increased to over 48,000 deaths yearly in the United States. Major depressive disorder (MDD) is the most common diagnosis among suicides, and identifying those at the highest risk for suicide is ...

Firoza Mamdani, Matthieu D. Weber, Blynn Bunney, Kathleen Burke… in Translational Psychiatry (2022)

Article

A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials

Criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD) as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the present document we used a Delph...

Luca Sforzini, Courtney Worrell, Melisa Kose, Ian M. Anderson… in Molecular Psychiatry (2022)

Article

Unraveling the opioid actions of S-ketamine and R-ketamine: comment on Bonaventura et al.

Boris D. Heifets, Brandon S. Bentzley, Nolan Williams… in Molecular Psychiatry (2021)

Article

Decoding the temporal nature of brain GR activity in the NFκB signal transition leading to depressive-like behavior

The fine-tuning of neuroinflammation is crucial for brain homeostasis as well as its immune response. The transcription factor, nuclear factor-κ-B (NFκB) is a key inflammatory player that is antagonized via an...

Young-Min Han, Min Sun Kim, Juyeong Jo, Daiha Shin, Seung-Hae Kwon… in Molecular Psychiatry (2021)

Article

Correction: Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD)

Supplementary Figure 1 and Supplementary Tables 1–4 have been re-uploaded so as to reflect the versions supplied during proofs stage. The publisher apologizes for the error in versioning. The HTML version of t...

Maurizio Fava, Marlene P. Freeman, Martina Flynn, Heidi Judge… in Molecular Psychiatry (2020)

Article

Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD)

Numerous placebo-controlled studies have demonstrated the ability of ketamine, an NMDA receptor antagonist, to induce rapid (within hours), transient antidepressant effects when administered intravenously (IV)...

Maurizio Fava, Marlene P. Freeman, Martina Flynn, Heidi Judge… in Molecular Psychiatry (2020)

Article

In Memoriam of George Gardos, MD

Alan F. Schatzberg in Neuropsychopharmacology (2020)

Article

Prefrontal networks dynamically related to recovery from major depressive disorder: a longitudinal pharmacological fMRI study

Due to lacking predictors of depression recovery, successful treatment of major depressive disorder (MDD) is frequently only achieved after therapeutic optimization leading to a prolonged suffering of patients...

Bernhard M. Meyer, Ulrich Rabl, Julia Huemer, Lucie Bartova… in Translational Psychiatry (2019)

Article

Corticotropin-releasing factor 1 receptor haplotype and cognitive features of major depression

Corticotropin-releasing factor signaling through CRF receptor type 1 (CRF₁) has been shown to contribute to learning and memory function. A haplotype of alleles T-A-T in a set of common polymorphisms in the gene ...

Elena Goetz Davis, Jennifer Keller, Joachim Hallmayer… in Translational Psychiatry (2018)

Article

Eberhard H Uhlenhuth

Alan F Schatzberg, Samuel J Keith in Neuropsychopharmacology (2016)

Article

A Cognitive–Emotional Biomarker for Predicting Remission with Antidepressant Medications: A Report from the iSPOT-D Trial

Depression involves impairments in a range of cognitive and emotional capacities. It is unknown whether these functions can inform medication choice when considered as a composite predictive biomarker. We test...

Amit Etkin, Brian Patenaude, Yun Ju C Song, Timothy Usherwood… in Neuropsychopharmacology (2015)

Article

Erratum: Ketamine: Promising Path or False Prophecy in the Development of Novel Therapeutics for Mood Disorders?

Correction to: Neuropsychopharmacology (2015) 40, 259–267; doi:10.1038/npp.2014.261; published online 22 October 2014 On page 262 (first paragraph under ‘Ketamine’s Abuse Liability: Mu Opioid Receptor Effects’...

Gerard Sanacora, Alan F Schatzberg in Neuropsychopharmacology (2015)

Article

Decreased Hypothalamic Functional Connectivity with Subgenual Cortex in Psychotic Major Depression

Hypothalamus communication with the rest of the brain and peripheral target tissues is critically important for many physiological and psychological functions. These functions include maintaining neuroendocrin...

Keith Sudheimer, Jennifer Keller, Rowena Gomez… in Neuropsychopharmacology (2015)