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Article
Open AccessEribulin induces micronuclei and enhances the nuclear localization of cGAS in triple-negative breast cancer cells
Eribulin (ERI), clinically utilized for locally advanced or metastatic breast tumors, has shown potential links to the immune system. Notably, the cGAS-STING pathway, a key component of innate immunity, has ga...
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Article
A prospective comparison study utilizing patient-reported outcomes of taxane-related peripheral neuropathy between nab-paclitaxel and standard paclitaxel in patients with breast cancer
Characteristics of taxane-induced peripheral neuropathy (PN) could be different between paclitaxel and nab-paclitaxel. The purpose of this prospective observational multicenter cohort study was to compare tri-...
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Article
Endoscopic mastectomy followed by immediate breast reconstruction with fat grafting for breast cancer
Although endoscopic mastectomy has been associated with good tolerance and enhanced patient satisfaction, limitations such as the implant or flap size for reconstruction with small incisions remain unresolved....
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Article
Open AccessDevelopment of a novel BRCAness score that predicts response to PARP inhibitors
BRCAness is a characteristic feature of homologous recombination deficiency (HRD) mimicking BRCA gene mutation in breast cancer. We hypothesized that a measure to quantify BRCAness that causes synthetic lethal...
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Article
Open AccessEnhanced immune response outperform aggressive cancer biology and is associated with better survival in triple-negative breast cancer
Although the value of tumor-infiltrating lymphocytes is well known, the clinical relevance of an increased immune response, specifically in breast cancer, has not been investigated across large cohorts of pati...
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Article
Abundance of reactive oxygen species (ROS) is associated with tumor aggressiveness, immune response, and worse survival in breast cancer
Reactive oxygen species (ROS) are oxygen-containing molecules that have high reactivity and play roles in protection or harm the cancer cells. We aimed to clarify the clinical relevance of ROS in breast cancer...
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Article
Low RUFY3 expression level is associated with lymph node metastasis in older women with invasive breast cancer
Sentinel lymph node biopsy is omitted in older women (≥ 70 years old) with clinical lymph node (LN)-negative hormone receptor-positive breast cancer as it does not influence adjuvant treatment decision-making....
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Article
Clinicopathological characteristics, practical treatments, prognosis, and clinical issues of older breast cancer patients in Japan
Minimal data are available to support the clinical management of older breast cancer patients. Consequently, the standard of care remains unclear. Our aim was to clarify the clinicopathological characteristics...
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Article
Open AccessDevelopment of an invasive ductal carcinoma in a contralateral composite nipple graft after an autologous breast reconstruction: a case report
Nipple-areola complex (NAC) reconstruction is a technique used in breast reconstructive surgery, which is performed during the final stage of breast reconstruction after total mastectomy of primary breast canc...
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Article
Open AccessEsophageal metastasis of breast cancer during endocrine therapy for pleural dissemination 21 years after breast surgery: a case report
The esophageal metastasis of breast cancer is rare. Moreover, it is extremely unusual for patients to experience the symptoms of esophageal metastasis during their lifetimes. We present a case of dysphagia cau...
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Article
Lnc RNA H19 is associated with poor prognosis in breast cancer patients and promotes cancer stemness
Aldehyde dehydrogenase1 (ALDH1) is widely accepted as a stem cell marker for normal breast as well as in breast cancer. Although the clinical impact of ALDH1 was observed in our previous study, we do not know ...
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Article
Erratum to: Objection to postoperative radiation therapy in breast cancer with one to three lymph nodes involvements
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Article
Objection to postoperative radiation therapy in breast cancer with one to three lymph nodes involvements
My arguments regarding postmastectomy radiotherapy (PMRT) for this case are based on the following 4 reasons: (1) high rate of local recurrence in the no PMRT group in the Early Breast Cancer Trialists’ Collab...
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Article
Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods
The tumor microenvironment is a determining factor for cancer biology and progression. Sphingosine-1-phosphate (S1P), produced by sphingosine kinases (SphKs), is a bioactive lipid mediator that regulates proce...
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Article
Effect of ALDH1 on prognosis and chemoresistance by breast cancer subtype
Aldehyde dehydrogenase 1 (ALDH1) has been identified as a breast cancer stem cell marker, but its value as a predictor of prognosis and chemoresistance is controversial. This study investigated the effect of A...
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Reference Work Entry In depth
Cancer and Inflammation
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Living Reference Work Entry In depth
Cancer and Inflammation
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Article
An improved syngeneic orthotopic murine model of human breast cancer progression
Breast cancer drug development costs nearly $610 million and 37 months in preclinical mouse model trials with minimal success rates. Despite these inefficiencies, there are still no consensus breast cancer pre...
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Article
K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5
IL-1 triggers IRF1 signaling, but the biological importance of this has remained uncertain. Kordula and colleagues show that an IL-1–IRF1 pathway is necessary for the selective induction of chemokines and ster...
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Article
High expression of ATP-binding cassette transporter ABCC11 in breast tumors is associated with aggressive subtypes and low disease-free survival
ATP-binding cassette (ABC) transporters are membrane proteins that efflux various compounds from cells, including chemotherapeutic agents, and are known to affect multidrug resistance. Recent reports disagree ...
