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Article
Contributions of lignification, tissue arrangement patterns, and cross-sectional area to whole-stem mechanical properties in Arabidopsis thaliana
Plant cells withstand mechanical stress originating from turgor pressure by robustly maintaining the mechanical properties of the cell wall. This applies at the organ scale as well; many plant stems act as pre...
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Article
Open AccessDevelopment of a novel BRCAness score that predicts response to PARP inhibitors
BRCAness is a characteristic feature of homologous recombination deficiency (HRD) mimicking BRCA gene mutation in breast cancer. We hypothesized that a measure to quantify BRCAness that causes synthetic lethal...
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Article
Open AccessLeft sided breast cancer is associated with aggressive biology and worse outcomes than right sided breast cancer
Breast cancer is more common on the left side than the right side. We aim to evaluate differences in clinicopathological and genomic characteristics based on laterality. We analyzed survival outcomes and clini...
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Article
Intratumoral PDGFB gene predominantly expressed in endothelial cells is associated with angiogenesis and lymphangiogenesis, but not with metastasis in breast cancer
Platelet-derived growth factor B (PDGFB) is known to play essential roles in angiogenesis and lymphangiogenesis during development, and tumor growth and vessel stabilization in experimental models. However, wh...
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Article
High RAD51 gene expression is associated with aggressive biology and with poor survival in breast cancer
Although the DNA repair mechanism is important in preventing carcinogenesis, its activation in established cancer cells may support their proliferation and aggravate cancer progression. RAD51 cooperates with B...
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Article
Beneficial effects of transdermal administration of tamoxifen on capsular contracture after breast implantation in murine models
Capsular contracture is the most common complication with smooth-type silicone implants. We investigated the preventive effect of an active metabolite of tamoxifen, 4-hydroxytamoxifen (4-OH TAM), on capsular c...
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Article
Open AccessSuccessful treatment of G-CSF-related aortitis with prednisolone during preoperative chemotherapy for breast cancer: a case report
With the introduction of dose-dense therapy, the use of primary pegfilgrastim (PEG-G) has been increasing in breast cancer treatment. A rare side effect of PEG-G is aortitis. We describe a case of PEG-G-induce...
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Article
Open AccessM1 Macrophage and M1/M2 ratio defined by transcriptomic signatures resemble only part of their conventional clinical characteristics in breast cancer
Tumor associated macrophages (TAMs) play a critical role in biology of various cancers, including breast cancer. In the current study, we defined “M1” macrophage and “M1”/“M2” ratio by transcriptomic signature...
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Article
Lymphovascular invasion in breast cancer is associated with gene expression signatures of cell proliferation but not lymphangiogenesis or immune response
While the prognostic relevance of lymphovascular invasion (LVI) in breast cancer is well known, its molecular biology is poorly understood. We hypothesized that pathologically determined LVI reflects molecular...
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Article
Open AccessBiologically Aggressive Phenotype and Anti-cancer Immunity Counterbalance in Breast Cancer with High Mutation Rate
While cancer cells gain aggressiveness by mutations, abundant mutations release neoantigens, attracting anti-cancer immune cells. We hypothesized that in breast cancer (BC), where mutation is less common, tumo...
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Article
Open AccessLate recurrence of breast cancer is associated with pro-cancerous immune microenvironment in the primary tumor
The fact that 20–40% of all breast cancer (BC) patients develop recurrence when 5 year survival is 90% strongly suggests that late recurrence, i.e. more than 5 years after diagnosis, is the remaining challenge...
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Article
Open AccessAuthor Correction: Pyrophosphate inhibits gluconeogenesis by restricting UDP-glucose formation in vivo
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
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Article
Open AccessPyrophosphate inhibits gluconeogenesis by restricting UDP-glucose formation in vivo
Pyrophosphate (PPi) is produced by anabolic reactions and serves as an energy donor in the cytosol of plant cells; however, its accumulation to toxic levels disrupts several common biosynthetic pathways and is...
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Chapter
Regulation of PPi Levels Through the Vacuolar Membrane H+-Pyrophosphatase
Inorganic pyrophosphate (PPi) is a high-energy compound, although the free energy change of its hydrolysis is approximately 60 % that of ATP. PPi is generated as a by-product of macromolecule biosyntheses in p...
