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Article
Open AccessA progressive and refractory case of breast cancer with Cowden syndrome
Cowden syndrome is a rare autosomal-dominant disease with a high risk of malignant tumors of the breast, commonly caused by germline mutations in the PTEN gene. Most breast cancers related to Cowden syndrome show...
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Article
Predictive and prognostic significance of BRCAness in HER2-negative breast cancer
BRCAness is characterized as the phenotypes shared between some sporadic tumors and BRCA1/2 mutation cancers resulting in defective homologous recombination. The predictive or prognostic value of BRCAness in HER2...
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Article
Analysis of plasma HER2 copy number in cell-free DNA of breast cancer patients: a comparison with HER2 extracellular domain protein level in serum
HER2 (human epidermal growth factor receptor 2) status has been evaluated in breast cancer (BC) tissues by immunohistochemistry or in situ hybridization. We evaluated HER2 copy number (CN) assay in plasma cell...
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Article
Therapeutic predictors of neoadjuvant endocrine therapy response in estrogen receptor-positive breast cancer with reference to optimal gene expression profiling
Neoadjuvant endocrine therapy (NAET) for estrogen receptor-positive primary breast cancer causes adequate tumor shrinkage, and is expected to be helpful for breast-conserving surgery, but the adaptation criter...
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Article
Open AccessClinical significance of plasma cell-free DNA mutations in PIK3CA, AKT1, and ESR1 gene according to treatment lines in ER-positive breast cancer
The somatic activation of PI3K/AKT pathway mutations, PIK3CA and AKT1, and ESR1 mutations in plasma cell-free DNA (cfDNA) has been studied as a non-invasive procedure to quickly assess and monitor disease progres...
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Article
Factors involved in early lenvatinib dose reduction: a retrospective analysis
Lenvatinib, a multi-tyrosine kinase inhibitor, has been proven to be an effective treatment option for patients with iodine-131-refractory thyroid cancer. Many adverse effects of lenvatinib have been reported;...
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Article
Open AccessPrevalence of ESR1 E380Q mutation in tumor tissue and plasma from Japanese breast cancer patients
ESR1 mutations have attracted attention as a potentially important marker and treatment target in endocrine therapy-resistant breast cancer patients. The E380Q mutation, which is one o...
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Article
Influence of the C5a–C5a receptor system on breast cancer progression and patient prognosis
Emerging evidence has shown activation of the complement system in cancer tissues and anaphylatoxin C5a release from C5 by cancer cells, suggesting C5a as a component in the cancer microenvironment. We reveale...
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Article
Successful ethinylestradiol therapy for a metastatic breast cancer patient with heavily pre-treated with endocrine therapies
The critical strategy leading to the success of endocrine therapy in metastatic breast cancer is ex tended duration of treatment. Here, we report a case with late-stage metastatic breast cancer who dramaticall...
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Article
Open AccessImmunohistochemical analysis in ethinylestradiol-treated breast cancers after prior long-term estrogen-deprivation therapy
Estrogen receptor (ER) positive breast cancer can often be treated by hormone therapy; however a certain population of ER-positive patients become resistant to hormone therapy after long-term hormone treatment...
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Article
Clinical significance of CYLD downregulation in breast cancer
Cylindromatosis (CYLD) is a tumor suppressor gene that is mutated in familial cylindromatosis, a rare autosomal dominant disorder associated with numerous benign skin adnexal tumors. CYLD is now known to regu...
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Article
Large-scale genoty** identifies 41 new loci associated with breast cancer risk
Douglas Easton, Per Hall and colleagues report meta-analyses of genome-wide association studies for breast cancer, including 10,052 cases and 12,575 controls, followed by genoty** using the iCOGS array in an...
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Article
Open AccessDifferential impact of body mass index and its change on the risk of breast cancer by molecular subtype: A case-control study in Japanese women
Body mass index (BMI) is an independent risk factor for luminal-type breast cancer in Western populations. However, it is unclear whether the impact of BMI differs according to breast cancer subtype in Japanes...
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Article
High recurrence risk and use of adjuvant trastuzumab in patients with small, HER2-positive, node-negative breast cancers
Five randomized trials of adjuvant trastuzumab have reported significant improvements in recurrence-free survival (RFS) and overall survival. However, patients with node-negative tumors 1 cm or smaller were ex...
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Article
A genetic risk predictor for breast cancer using a combination of low-penetrance polymorphisms in a Japanese population
Genome-wide association studies (GWASs) have identified genetic variants associated with breast cancer. Most GWASs to date have been conducted in women of European descent, however, and the contribution of the...
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Article
Stromal sarcoma of the breast with lung metastases showing a clinical complete response to doxorubicin plus ifosfamide treatment: Report of a case
A 29-year-old woman presented with a painful right breast tumor, measuring 15 cm in diameter, which had progressed rapidly over 3 months. Core needle biopsy of the tumor revealed a malignant mesenchymal tumor....
