59 Result(s)

Article

Family history and gastric cancer incidence and mortality in Asia: a pooled analysis of more than half a million participants

The family history of gastric cancer holds important implications for cancer surveillance and prevention, yet existing evidence predominantly comes from case–control studies. We aimed to investigate the associ...

Dan Huang, Minkyo Song, Sarah Krull Abe, Md. Shafiur Rahman… in Gastric Cancer (2024)

Article

Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation

Observational studies suggest that abnormal glucose metabolism and insulin resistance contribute to colorectal cancer; however, the causal association remains unknown, particularly in Asian populations. A two-...

Akiko Hanyuda, Atsushi Goto, Ryoko Katagiri, Yuriko N. Koyanagi… in Scientific Reports (2023)

Article

Author Correction: Response to antiviral therapy for chronic hepatitis C and risk of hepatocellular carcinoma occurrence in Japan: a systematic review and meta-analysis of observational studies

Yoko Yamagiwa, Keitaro Tanaka, Keitaro Matsuo, Keiko Wada… in Scientific Reports (2023)

Article

Response to antiviral therapy for chronic hepatitis C and risk of hepatocellular carcinoma occurrence in Japan: a systematic review and meta-analysis of observational studies

In Japan, hepatocellular carcinoma (HCC) is a leading cause of cancer mortality and hepatitis C virus infection is a major cause of HCC. We conducted a systematic review and meta-analysis of published studies ...

Yoko Yamagiwa, Keitaro Tanaka, Keitaro Matsuo, Keiko Wada… in Scientific Reports (2023)

Article

Association of 25-hydroxyvitamin D with risk of overall and colorectal cancer among Japanese using a Mendelian randomization approach

The association between vitamin D and total and colorectal cancer risk was inconsistent in observational studies. We conducted Mendelian randomization approach in which the effect of confounding might be reduc...

Ryoko Katagiri, Atsushi Goto, Shiori Nakano, Masahiro Nakatochi… in Scientific Reports (2023)

Article

Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry

Low-frequency variants play an important role in breast cancer (BC) susceptibility. Gene-based methods can increase power by combining multiple variants in the same gene and help identify target genes.

Stefanie H. Mueller, Alvina G. Lai, Maria Valkovskaya… in Genome Medicine (2023)

Article

Relevance of the MHC region for breast cancer susceptibility in Asians

Human leukocyte antigen (HLA) genes play critical roles in immune surveillance, an important defence against tumors. Imputing HLA genotypes from existing single-nucleotide polymorphism datasets is low-cost and...

Peh Joo Ho, Alexis Jiaying Khng, Benita Kiat-Tee Tan, Ern Yu Tan… in Breast Cancer (2022)

Article

Association of perceived stress and co** strategies with the renal function in middle-aged and older Japanese men and women

Elucidating the risk factors for chronic kidney disease is important for preventing end-stage renal disease and reducing mortality. However, little is known about the roles of psychosocial stress and stress co...

Kayoko Koga, Megumi Hara, Chisato Shimanoe, Yuichiro Nishida… in Scientific Reports (2022)

Article

Association between plasma levels of homocysteine, folate, and vitamin B₁₂, and dietary folate intake and hypertension in a cross-sectional study

There are few studies examining the association between homocysteine (Hcy) level and the risk of hypertension with consideration for folate and vitamin B₁₂ as related to Hcy level. We simultaneously examined the ...

Takashi Tamura, Nagato Kuriyama, Teruhide Koyama, Etsuko Ozaki… in Scientific Reports (2020)

Article

European polygenic risk score for prediction of breast cancer shows similar performance in Asian women

Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women u...

Weang-Kee Ho, Min-Min Tan, Nasim Mavaddat, Mei-Chee Tai… in Nature Communications (2020)

Article

Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer

Pancreatic cancer is the fourth leading cause of cancer-related deaths in Japan. To identify risk loci, we perform a meta-analysis of three genome-wide association studies comprising 2,039 pancreatic cancer pa...

Yingsong Lin, Masahiro Nakatochi, Yasuyuki Hosono, Hidemi Ito… in Nature Communications (2020)

Article

Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk

In breast cancer, high levels of homeobox protein Hox-B13 (HOXB13) have been associated with disease progression of ER-positive breast cancer patients and resistance to tamoxifen treatment. Since HOXB13 p.G84E is...

**g**g Liu, Wendy J. C. Prager - van der Smissen… in Scientific Reports (2020)

Article

Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants

Known risk variants explain only a small proportion of breast cancer heritability, particularly in Asian women. To search for additional genetic susceptibility loci for breast cancer, here we perform a meta-an...

**ang Shu, Jirong Long, Qiuyin Cai, Sun-Seog Kweon, Ji-Yeob Choi… in Nature Communications (2020)

Article

Identification of two novel breast cancer loci through large-scale genome-wide association study in the Japanese population

Genome-wide association studies (GWAS) have successfully identified about 70 genomic loci associated with breast cancer. Owing to the complexity of linkage disequilibrium and environmental exposures in differe...

Siew-Kee Low, Yoon Ming Chin, Hidemi Ito, Keitaro Matsuo… in Scientific Reports (2019)