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Open AccessTargeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment
Novel therapies are urgently needed for epithelial ovarian cancer (EOC), the most lethal gynecologic malignancy. In addition, therapies that target unique vulnerabilities in the tumor microenvironment (TME) of...
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Open AccessThe USP10-HDAC6 axis confers cisplatin resistance in non-small cell lung cancer lacking wild-type p53
Ubiquitin-specific peptidase 10 (USP10) stabilizes both tumor suppressors and oncogenes in a context-dependent manner. However, the nature of USP10’s role in non-small cell lung cancer (NSCLC) remains unclear....
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Open AccessChronic p27Kip1 Induction by Dexamethasone Causes Senescence Phenotype and Permanent Cell Cycle Blockade in Lung Adenocarcinoma Cells Over-expressing Glucocorticoid Receptor
Dexamethasone (Dex), co-administered to lung adenocarcinoma patients with pemetrexed chemotherapy, protects against pemetrexed cytotoxicity by inducing reversible G1 arrest, reflected by the effect of Dex on F...
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Discoidin Domain Receptors in Lung Cancer
Lung cancer is the leading cause of cancer deaths in the United States and Europe. Tyrosine kinases, involved in signal transduction pathways, are frequently mutated in lung cancer, and novel therapeutic inter...
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Open AccessThe cyclin-like protein Spy1/RINGO promotes mammary transformation and is elevated in human breast cancer
Spy1 is a novel 'cyclin-like' activator of the G1/S transition capable of enhancing cell proliferation as well as inhibiting apoptosis. Spy1 protein levels are tightly regulated during normal mammary developme...
