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  1. No Access

    Article

    Senescence-associated secretory proteins induced in lung adenocarcinoma by extended treatment with dexamethasone enhance migration and activation of lymphocytes

    There is a need to improve response rates of immunotherapies in lung adenocarcinoma (AC). Extended (7–14 days) treatment of high glucocorticoid receptor (GR) expressing lung AC cells with dexamethasone (Dex) i...

    Prahlad Parajuli, Rayna Rosati, Hirva Mamdani… in Cancer Immunology, Immunotherapy (2023)

  2. Article

    Open Access

    Clinical association of progesterone receptor isoform A with breast cancer metastasis consistent with its unique mechanistic role in preclinical models

    Luminal breast cancer (L-BCa) comprises the majority of incurable, distally metastatic breast cancer cases. Estrogen supports growth of L-BCa cells but suppresses invasiveness. Estrogen also induces the proges...

    Rayna Rosati, Kailey Oppat, Yanfang Huang, Seongho Kim, Manohar Ratnam in BMC Cancer (2020)

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  3. No Access

    Article

    Racial differences in estrogen receptor staining levels and implications for treatment and survival among estrogen receptor positive, HER2-negative invasive breast cancers

    African American women (AAW) die more frequently from estrogen receptor (ER) positive breast cancer than European American women (EAW). We investigated the relationship between race, percent ER staining, treat...

    Kristen S. Purrington, David Gorski… in Breast Cancer Research and Treatment (2020)

  4. Article

    Open Access

    Chronic p27Kip1 Induction by Dexamethasone Causes Senescence Phenotype and Permanent Cell Cycle Blockade in Lung Adenocarcinoma Cells Over-expressing Glucocorticoid Receptor

    Dexamethasone (Dex), co-administered to lung adenocarcinoma patients with pemetrexed chemotherapy, protects against pemetrexed cytotoxicity by inducing reversible G1 arrest, reflected by the effect of Dex on F...

    Mugdha Patki, Thomas McFall, Rayna Rosati, Yanfang Huang… in Scientific Reports (2018)

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