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  1. Article

    Open Access

    Hotspot Hunter: a computational system for large-scale screening and selection of candidate immunological hotspots in pathogen proteomes

    T-cell epitopes that promiscuously bind to multiple alleles of a human leukocyte antigen (HLA) supertype are prime targets for development of vaccines and immunotherapies because they are relevant to a large p...

    Guang Lan Zhang, Asif M Khan, Kellathur N Srinivasan, AT Heiny… in BMC Bioinformatics (2008)

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  2. Article

    Open Access

    Identification of human-to-human transmissibility factors in PB2 proteins of influenza A by large-scale mutual information analysis

    The identification of mutations that confer unique properties to a pathogen, such as host range, is of fundamental importance in the fight against disease. This paper describes a novel method for identifying a...

    Olivo Miotto, AT Heiny, Tin Wee Tan, J Thomas August, Vladimir Brusic in BMC Bioinformatics (2008)

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  3. Article

    Open Access

    Large-scale analysis of antigenic diversity of T-cell epitopes in dengue virus

    Antigenic diversity in dengue virus strains has been studied, but large-scale and detailed systematic analyses have not been reported. In this study, we report a bioinformatics method for analyzing viral antig...

    Asif M Khan, AT Heiny, Kenneth X Lee, KN Srinivasan, Tin Wee Tan… in BMC Bioinformatics (2006)

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