23 Result(s)
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Barbara E. K. Klein
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Article
Inflammation, metabolic dysregulation and environmental neurotoxins and risk of cognitive decline and impairment in midlife
Age-related declines in cognitive function may begin in midlife.
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Open AccessRetinal microvascular signs and risk of diabetic kidney disease in asian and white populations
The objective was to examine prospectively the association between retinal microvascular signs and development of diabetic kidney disease (DKD) in Asian and White populations. We analysed two population-based ...
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Open AccessCommon variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract
Nuclear cataract is the most common type of age-related cataract and a leading cause of blindness worldwide. Age-related nuclear cataract is heritable (h2 = 0.48), but little is known about specific genetic facto...
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Open AccessYI 1.3 Retinal Microvascular Calibers and Incident Depressive Symptoms: The Multi-Ethnic Study of Atherosclerosis
Cerebral microvascular dysfunction may contribute to depression via disruption of brain structures involved in mood regulation, but evidence is scarce. The retina allows for direct visualisation of a microvasc...
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Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error
Refractive errors, including myopia, are the most frequent eye disorders worldwide and an increasingly common cause of blindness. This genome-wide association meta-analysis in 160,420 participants and replicat...
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Open AccessMeta-genome-wide association studies identify a locus on chromosome 1 and multiple variants in the MHC region for serum C-peptide in type 1 diabetes
The aim of this study was to identify genetic variants associated with beta cell function in type 1 diabetes, as measured by serum C-peptide levels, through meta-genome-wide association studies (meta-GWAS).
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Predictors of electrocardiographic abnormalities in type 1 Diabetes: the Wisconsin Epidemiologic Study of Diabetic Retinopathy
To determine the incidence and determinants of develo** abnormalities on the 12-lead electrocardiogram (ECG) in persons with type 1 diabetes.
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Open AccessAdequate vitamin D status is associated with the reduced odds of prevalent diabetic retinopathy in African Americans and Caucasians
Vitamin D status has been hypothesized to protect against development of diabetic retinopathy via its anti-inflammatory and anti-angiogenic properties. Additionally, in vitro and in vivo studies suggest vitami...
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Open AccessMeta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error
Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM con...
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Article
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants
Iris Heid, Gonçalo Abecasis, Sudha Iyengar and colleagues report the results of a large genome-wide association meta-analysis of macular degeneration based on over 43,000 subjects. They identify 16 new risk lo...
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Article
Retinal microvascular calibre and risk of diabetes mellitus: a systematic review and participant-level meta-analysis
The calibre of the retinal vessels has been linked to diabetes mellitus but studies have not shown consistent results. We conducted a participant-level meta-analysis to evaluate the association between retinal...
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Open AccessThe association of previously reported polymorphisms for microvascular complications in a meta-analysis of diabetic retinopathy
We investigated the association of signals from previous GWAS and candidate gene meta-analyses for diabetic retinopathy (DR) or nephropathy (DN), as well as an EPO variant in meta-analyses of severe (SDR) and mil...
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Open AccessGWAS identifies an NAT2 acetylator status tag single nucleotide polymorphism to be a major locus for skin fluorescence
Skin fluorescence (SF) is a non-invasive marker of AGEs and is associated with the long-term complications of diabetes. SF increases with age and is also greater among individuals with diabetes. A familial cor...
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Ten-year change in self-rated quality of life in a type 1 diabetes population: Wisconsin Epidemiologic Study of Diabetic Retinopathy
To investigate a 10-year change of quality of life and associated factors in a population with type 1 diabetes.
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Erratum: Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia
Nat. Genet. 45, 314–318 (2013); doi:10.1038/ng.2554; published online 10 February 2013; corrected after print 9 May 2013 In the version of this article initially published, the affiliations of Daniel W.H. Ho w...
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Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia
Caroline Klaver and colleagues report a meta-analysis for refractive error and myopia, including 37,382 individuals from 27 European studies and 8,376 individuals from 5 Asian studies, as part of the Consortiu...
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Intensity of Salt Taste and Prevalence of Hypertension Are Not Related in the Beaver Dam Offspring Study
Standard clinical advice for the prevention and treatment of hypertension includes limitation of salt intake. Previous studies of the association between perception of salt taste and hypertension prevalence ha...
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Article
Health-related quality of life before and after a breast cancer diagnosis
While many reports describe health-related quality of life (QOL) among breast cancer survivors, few compare QOL before and after diagnosis and whether changes in QOL substantially differ from changes experienc...
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Medical Approaches to Preventing Vision Loss from Diabetic Retinopathy
Data from the Diabetic Retinopathy Study [1] and the Early Treatment Diabetic Retinopathy Study [2], demonstrated the efficacy of photocoagulation treatment in preventing visual loss associated with proliferative...
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Leisure time, sunlight exposure and cataracts
Leisure time sunlight exposure is a small or insignificant portion of total sunlight exposure experienced by most people at high risk for cataract. Few studies have been undertaken to evaluate a possible causa...
