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  1. No Access

    Article

    Prognostic Significance of Tumor-Associated Inflammation in Renal Cell Carcinoma

    This study analyzed tumor-associated inflammation by assessing the expression of cyclophilin A (CypA) and TNF in samples of kidney tumors of various histological types. It was shown that different histological...

    O. V. Kovaleva, P. A. Podlesnaya… in Bulletin of Experimental Biology and Medic… (2024)

  2. No Access

    Article

    Soluble B7-H3 in Colorectal Cancer

    We present the results of comparative ELISA of the concentration of soluble form of immunity checkpoint B7-H3 (sB7-H3) in the serum of patients with colorectal cancer (CRC) at different stages before treatment...

    O. V. Kovaleva, A. N. Gratchev… in Bulletin of Experimental Biology and Medic… (2023)

  3. No Access

    Article

    Clinical Significance of CD66b Expression in Non-Small Cell Lung Cancer

    We studied the expression of CD66b (a protein of the cancer-embryonic antigen family, expressed mainly in neutrophils) in tumor and stromal cells of non-small cell lung cancer (93 samples). The number of CD66b+ n...

    O. V. Kovaleva, P. A. Podlesnaya… in Bulletin of Experimental Biology and Medic… (2023)

  4. No Access

    Article

    Transcriptome of Lung Cancer Cells Resistant to the Cytotoxic Activity of Macrophages

    The role of the immune system in tumor progression has been the subject of research for more than 100 years since Paul Ehrlich hypothesized that the presence of the immune system limits the occurrence of cance...

    O. V. Kovaleva, P. A. Podlesnaya, M. V. Vasileva… in Doklady Biochemistry and Biophysics (2022)

  5. No Access

    Article

    Cytotoxic Activity of Macrophages as a Tumor Malignancy Factor

    An experimental cell-based model was developed to study antibody-independent cytotoxic activity of macrophages that allows selection of derivative tumor cells resistant to this activity and clarification of th...

    P. A. Podlesnaya, O. V. Kovaleva… in Bulletin of Experimental Biology and Medic… (2022)

  6. No Access

    Article

    Soluble B7-H3 in Ovarian Cancer and Its Predictive Value

    The content of the soluble form of protein of the key point of immunity B7-H3 (sB7-H3) in the blood plasma of 75 patients with epithelial ovarian cancer before treatment was measured by ELISA. It is known that...

    O. V. Kovaleva, T. P. Belova… in Bulletin of Experimental Biology and Medic… (2021)

  7. No Access

    Article

    Immunosuppression Factors PD-1, PD-L1, and IDO1 and Colorectal Cancer

    Due to the low efficiency of immunotherapy for colorectal cancer (CRC), it is extremely promising and relevant to study the mechanisms of immunosuppression. In this work, a comprehensive study of the expressio...

    O. V. Kovaleva, M. A. Rashidova, A. N. Gratchev… in Doklady Biochemistry and Biophysics (2021)

  8. No Access

    Article

    Expression of Transcription Factor PU.1 in Stromal Cells as a Prognostic Marker in Non-Small Cell Lung Cancer

    Transcription factor PU.1 is involved in hematopoiesis and is expressed in various cells of the inflammatory infiltrate of the tumor stroma, mainly in macrophages. The expression of PU.1 in 100 samples of non-...

    O. V. Kovaleva, M. A. Rashidova… in Bulletin of Experimental Biology and Medic… (2021)

  9. No Access

    Article

    Mathematical model of cellular transport network self-organization and functioning

    Contemporary cell investigation methods permit us to describe the molecular transport mechanisms of intracellular substances and cell components. Analysis of the completeness and the consistency of the existin...

    K. A. Novikov, A. A. Romanyukha… in Mathematical Models and Computer Simulatio… (2015)