12 Result(s)
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Article
Stoffwechsel
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Untersuchungen zum cytostatischen Wirkungsmechanismus der Vitamin-A-Säure
The cytostatic effects of vitamin-A-acid on Ehrlich-ascites tumor cells in-vitro and on some cell-free enzyme systems were investigated. In the presence of various vitamin-A-acid concentrations the rates of 14C-t...
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Weitere Anreicherung eines gewebsspezifischen Inhibitors der Lymphopoese (Lymphozytenchalon?)
A partially purified calf spleen extract, which exhibits the properties of a lymphocyte chalone (tissue-specific, species non-specific, non-toxic and reversible acting, endogenous inhibitor of cell proliferati...
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Upregulation of HER-2/neu by Ovarian Ablation: Results of a Randomized Trial Comparing Leuprorelin to CMF as Adjuvant Therapy in Node-positive Breast Cancer Patients
Purpose. HER-2/neu oncogene expression is modulated by an estrogen-sensitive binding site in the HER-2/neu promoter. Utilizing the circulating antigen of HER-2/neu in serum (sHER-2/neu) as a surrogate marker we ...
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Options thérapeutiques
Dans cette section sont décrites des techniques opératoires souvent utilisées sur les organes génitaux masculins. Ces interventions sont souvent déléguées à des médecins inexpérimentés, ce qui peut provoquer d...
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Open AccessDetermination of Ras-GTP and Ras-GDP in patients with acute myelogenous leukemia (AML), myeloproliferative syndrome (MPS), juvenile myelomonocytic leukemia (JMML), acute lymphocytic leukemia (ALL), and malignant lymphoma: assessment of mutational and indirect activation
The 21-kD protein Ras of the low-molecular-weight GTP-binding (LMWG) family plays an important role in transduction of extracellular signals. Ras functions as a ‘molecular switch’ in transduction of signals fr...
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Open AccessAcute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation
A role for WNT signalling in gastric carcinogenesis has been suggested due to two major observations. First, patients with germline mutations in adenomatous polyposis coli (APC) are susceptible to stomach poly...
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KRAS allel-specific activity of sunitinib in an isogenic disease model of colorectal cancer
To investigate the impact of different KRAS mutations on treatment with the tyrosine kinase inhibitor sunitinib in SW48 colorectal cancer cell line variants.
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Erweiterter RAS-Mutationsstatus
Die wichtigsten, für das metastasierte kolorektale Karzinom (mKRK) bislang zugelassenen zielgerichteten Substanzen sind Cetuximab (Erbitux®) und Panitumumab (Vectibix®), beides Antikörper gegen den „epidermal ...
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Diagnostik der primären ziliären Dyskinesie
Die primäre ziliäre Dyskinesie (PCD) ist eine seltene angeborene Erkrankung der Zilien, die sich zumeist im respiratorischen System manifestiert.
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Open AccessLeft-sided primary tumors are associated with favorable prognosis in patients with KRAS codon 12/13 wild-type metastatic colorectal cancer treated with cetuximab plus chemotherapy: an analysis of the AIO KRK-0104 trial
AIO KRK-0104 investigated first-line therapy of metastatic colorectal cancer (mCRC) with cetuximab, capecitabine and irinotecan versus cetuximab, capecitabine and oxaliplatin. This analysis investigated the im...
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Open AccessCancer of unknown primary (CUP) through the lens of precision oncology: a single institution perspective
For patients with cancer of unknown primary (CUP), treatment options are limited. Precision oncology, the interplay of comprehensive genomic profiling (CGP) and targeted therapies, aims to offer additional tre...
