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Chapter
The Charge Translocating Reactions of the bc Complexes and Cytochrome Oxidase
The bc complex and cytochrome oxidase are two of the major respiratory electron transfer complexes of mammalian mitochondria. Their catalytic cycles result in the net translocation of a proton across the lipid bi...
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Article
The effects of glucose-dependent insulinotropic polypeptide infused at physiological concentrations in normal subjects and Type 2 (non-insulin-dependent) diabetic patients on glucose tolerance and B-cell secretion
The effects of porcine glucose-dependent insulinotropic polypeptide given by continuous intravenous infusion in normal subjects (n=6) and Type 2 (non-insulin-dependent) diabetic patients (n=6) have been investiga...
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Article
Cyclic-AMP-dependent phosphorylation of glicentin
Highly purified glicentin , a 69-amino-acid-residue peptide isolated from porcine intestine that contains the full sequence of glucagon and is probably biosynthetically related to glucagon, is a substrate for ...
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Chapter
Glucagon, Glicentin, and Related Peptides
The observations that the canine and human intestine contain glucagon-like im-munoreactivity (GLI) (Unger et al. 1961, 1968), that the gastrointestinal tract of the dog contains hyperglycemic factors (Makman and ...
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Article
Glicentin inhibits gastric acid secretion in the rat
Gut glucagon-like immunoreactants (GLIs) are peptides of enteric origin, which have immunoreactivity in common with pancreatic glucagon. First reported in the intestine by Unger et al.1, GLIs are concentrated in ...
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Article
Glucagon and glicentin immunoreactive cells in human colon
An immunohistochemical study of glucagon and glicentin immunoreactive endocrine cells in the human colon epithelium was performed. Serial sections and qualitative analysis show a cell population containing bot...
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Article
Relationship of glicentin to proglucagon and glucagon in the porcine pancreas
We have previously1 isolated from porcine small intestine a peptide known as glicentin. The C-terminal portion of glicentin consists of the sequence of glucagon extended at its C terminus by an octapeptide2,3, an...
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Article
Glucagon- and glicentin-immunoreactive cells in the human digestive tract
The distribution and cellular location of substances reacting with anti-glucagon or anti-glicentin sera, i.e., glucagon-like and glicentin-like immunoreactivities, were studied in the human digestive tract usi...
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Article
The response of Gastric Inhibitory Polypeptide (GIP) and insulin to glucose in duodenal ulcer patients
The response of Gastric Inhibitory Polypeptide (GIP) and insulin to a 50 g oral glucose tolerance test (OGTT) and an intravenous glucose infusion (IVGI), which copied the changes in plasma glucose concentratio...
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Chapter and Conference Paper
Heterogeneity of Gut Glucagon-Like Immunoreactivity (GLI)
One component of gut glucagon-like immunoreactivity (GLI-1) has been purified and characterized. It is proposed that gut GLIs of a given species contain the full homologous glucagon sequence and are immunologi...
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Chapter and Conference Paper
Isogenic and Allogenic Transplatation of Isolated Langerhans Islets into the Liver
The discovery of insulin by Banting and Best more than fifty years ago has saved lives of multitude of diabetic patients but the disabling late complications of the disease are not prevented by this treatment....
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Article
Eighth annual meeting of the European Association for the Study of Diabetes
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Article
The insulin releasing activities of extracts of pork intestine
Acid-ethanol extracts were prepared from pork ileum + jejunum (TOT), heart and duodenum. TOT was fractionated by column chromatography. The insulin-releasing activities (IRA) of these materials were determined...
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Article
The role of the liver in the disposal of orally administered 14C-glucose in the normal rat
6-14C-glucose (specific activity 6.0 μCi/g) was administered by oesophageal tube to fasted normal rats; the load was 1.5 g/kg. Rats were killed, in groups, at 0, 10, 20, 30, 60, 120 and 180 min after administrati...
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Article
British Diabetic Association Abstracts Medical and Scientific Section, Autumn Meeting
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Article
The effect of insulin on the glycogen metabolism of isolated fat cells
(1) Des adipocytes isolés à partir du tissu adipeux épididymaire du rat ont été incubés dans des milieux contenant du glucose (114C) et des concentrations variables d'insuline. La quantité de glucose (114C) trans...
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Article
British Diabetic Association Abstracts
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Article
The effect of insulin on the formation of glycogen by the mouse diaphragm in vitro
Insulinzugabe in ein Milieu mit (U14C) Glukose stimuliert gleichfalls die Bildung des radio-wie des nicht-radioaktiven Glykogens in vitro. Insulin vermehrt ebenso die Bildung von Glykogen durch das Mäusezwerchfel...
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Article
A bioassay for insulin using thein situ mouse diaphragm
Description d'une méthode de détermination de l'insuline utilisant le diaphragme de sourisin situ. Les résultats concordent avec un essai similairein vitro.
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Article
A diaphragm bioassay for the measurement of total ‘insulin-like activity’ and of ‘antigenic insulin’ in serum
Description d'une méthode de détermination de l'insuline antigénique utilisant le diaphragme de souris avec et sans addition d'anticorps anti-insuline préalablement précipités par de l'anti-γ-globuline.