26 Result(s)

Article

Radionuclides for Betavoltaic Nuclear Batteries: Micro Scale, Energy-Intensive Batteries with Long-Term Service Life

Product miniaturization of micro-engineering technology with energy consumption at the level of milli- and microwatts requires a corresponding reduction in the characteristic dimensions of personal energy sour...

L. A. Tsvetkov, S. L. Tsvetkov, A. A. Pustovalov, V. N. Verbetskii… in Radiochemistry (2022)

Article

Antihypotensive activity of 2-acetylamino-5,6-dihydro-4H-1,3-thiazine for an endotoxic shock model in rats

The high anti-hypotonic activity of the new NOS inhibitor 2-acetylamino-5,6-dihydro-4H-1,3-thiazine hydro-bromide was demonstrated for an endotoxic shock model in rats.

M. V. Filimonova, T. P. Trofimova, G. S. Borisova… in Pharmaceutical Chemistry Journal (2012)

Article

Adsorption of NO synthase inhibitor on dehydroxylated silica

A series of thiazine derivatives with the NO inhibiting effect was synthesized. These derivatives can be used in the treatment of gastrointestinal diseases, as well as antihypotensive (antishock) drugs. The po...

T. D. Khokhlova, A. A. Mandrugin… in Protection of Metals and Physical Chemistr… (2010)

Article

Synthesis of putative radioprotectors on the basis of cyclic isotioureas derivatives

The present work deals with the synthesis of sixteen compounds with putative inhibiting activity towards NO-synthase on the basis of 2-amino-2-thiazoline and 2-amino-5,6-dihydro-4H-1,3-thiazine.

T. P. Trofimova, O. N. Zefirova, A. A. Mandrugin… in Moscow University Chemistry Bulletin (2009)

Article

Synthesis and study of NOS-inhibiting activity of 2-N-acylamino-5,6-dihydro-4H-1,3-thiazine

The synthesis and results of in vitro and in vivo testing of 2-N-acetylamino-, 2-N-benzoylamino-,2-N-cyclohexanecarbonylamino-, and 2-N-(1-adamantanecarbonyl)amino-5,6-dihydro-4H-1,3-thiazines for NOS-inhibiting ...

T. P. Trofimova, O. N. Zefirova, A. A. Mandrugin… in Moscow University Chemistry Bulletin (2008)

Article

Nitric oxide inhibitor activity of 2-amino-2-thiazoline derivatives

A series of 2-amino-2-thiazoline derivatives have been synthesized and characterized with respect to NOS-inhibitor activity in vivo. It was established that the dimensions of the substituents in 2-N-mono-and 2-N,...

A. A. Mandrugin, T. P. Trofimova, V. M. Fedoseev… in Pharmaceutical Chemistry Journal (2007)

Article

Synthesis of new 2-amino-5-hydroxymethyl-2-thiazolines

A simple and convenient method is proposed for the synthesis of 2-amino-5-hydroxymethylthiazolines with various substituents in the amino group, which is based on hydrolysis of the corresponding 5-halomethyl d...

T. P. Trofimova, A. N. Pushin, A. N. Proshin… in Chemistry of Heterocyclic Compounds (2007)

Article

Structure and activity of NO synthase inhibitors specific to the L-arginine binding site

Synthesis of compounds containing a fragment similar to the guanidine group of L-arginine, which is a substrate of nitric oxide synthase (NOS), is the main direction in creating NOS inhibitors. The inhibitory ...

S. Ya. Proskuryakov, A. G. Konoplyannikov, V. G. Skvortsov… in Biochemistry (Moscow) (2005)

Article

Structure and activity of NO synthase inhibitors specific to the L-arginine binding site

Synthesis of compounds containing a fragment similar to the guanidine group of L-arginine, which is a substrate of nitric oxide synthase (NOS), is the main direction in creating NOS inhibitors. The inhibitory ...

S. Ya. Proskuryakov, A. G. Konoplyannikov, V. G. Skvortsov… in Biochemistry (Moscow) (2005)

Article

Radiotracer Diagnostics of Graphite Intercalation Compounds with Sulfuric and Acetic Acids

The electrochemical intercalation of graphite in H₂SO₄–CH₃COOH solutions is investigated by the radiotracer method in combination with autoradiography. The results attest to the formation of a stage I ternary int...

N. V. Maksimova, V. S. Leshin, A. A. Mandrugin, V. I. Korobkov… in Inorganic Materials (2004)

Article

Effect of NO synthase inhibitor 2-amino-5,6-dihydro- 4H-1,3-thiazine on endotoxin-induced changes in hemodynamic parameters and respiration in rats

We studied the effect of NO synthase inhibitor 2-amino-5,6-dihydro-4H-1,3-thiazine (2-ADT) on the cardiovascular system in rats with endotoxic shock. Blood pressure, heart rate, and respiratory rate were recorded...

S. Ya. Proskuryakov, M. V. Filimonova… in Bulletin of Experimental Biology and Medic… (2004)

Article

Effect of NO synthase inhibitor 2-amino-5,6-dihydro-4H-1,3-thiazine on endotoxin-induced changes in hemodynamic parameters and respiration in rats

We studied the effect of NO synthase inhibitor 2-amino-5,6-dihydro-4H-1,3-thiazine (2-ADT) on the cardiovascular system in rats with endotoxic shock. Blood pressure, heart rate, and respiratory rate were recorded...

S. Ya. Proskuryakov, M. V. Filimonova… in Bulletin of Experimental Biology and Medic… (2004)

Article

Effect of NO synthase inhibitor 2-amino-5,6-dihydro- 4H-1,3-thiazine on endotoxin-induced changes in hemodynamic parameters and respiration in rats

We studied the effect of NO synthase inhibitor 2-amino-5,6-dihydro-4H-1,3-thiazine (2-ADT) on the cardiovascular system in rats with endotoxic shock. Blood pressure, heart rate, and respiratory rate were recorded...

S. Ya. Proskuryakov, M. V. Filimonova… in Bulletin of Experimental Biology and Medic… (2004)

Article

Solvolysis of 2-Amino-2-thiazoline Derivatives by Aliphatic Amino Alcohols

The opening of the thiazoline ring upon the action of amino alcohols was studied. The effects of the reagent ratio and structures of the heterocycles and amino alcohols on aminolysis were investigated. A new m...

A. A. Mandrugin, V. M. Fedoseev, O. V. Dubovaya… in Chemistry of Heterocyclic Compounds (2002)

Article

NO-Inhibiting and Vasotropic Activity of Some Compounds with Thioamidine Group

Using the method of electron paramagnetic spectroscopy we demonstrated that thiazine-thiazoline compounds and aminoethyl isothiourea containing the thioamidine group inhibit NO production in the liver of endot...

S. Ya. Proskuryakov, N. G. Kucherenko… in Bulletin of Experimental Biology and Medic… (2002)

Article

New Method for the Synthesis of N'-Monoderivatives of 2(3)-Guanidinoalkanethiols by the Aminolysis of Heterocycles

A study of the solvolysis of heterocycles under the influence of amines uncovered a new ring-opening reaction of heterocyclic rings to give N'-monoderivatives of 2(3)-guanidinoalkanethiols. A new preparative m...

A. A. Mandrugin, V. M. Fedsoseev, A. A. Rodunin… in Chemistry of Heterocyclic Compounds (2001)

Article

Conversion of Heterocycles of The Dihydrothiazine–Thiazoline Series in Aqueous Solutions

When heterocycles of the dihydrothiazine–thiazoline series are treated with an aqueous solution of base, they undergo ring opening, leading to formation of ureidoalkanethiols. Study of solvolysis of the hetero...

A. A. Mandrugin, V. M. Fedoseev, M. N. Semenenko… in Chemistry of Heterocyclic Compounds (2000)

Article

The influence of grafted functional groups on the adsorption properties of silica

The adsorption properties of silica gel with grafted aminopropyl and guanidinoethanethiol (GET) groups were studied by the techniques of adsorption under static conditions and gas chromatography. It was shown ...

T. M. Roshchina, V. Ya. Davydov, K. B. Gurevich… in Russian Chemical Bulletin (1997)

Article

Synthesis of N-derivatives of guanidinoethanethiols and their antiradiation activity on the yeastSaccharomyces Cerevisiae

A. A. Rodyunin, L. T. Zolotareva, A. A. Mandrugin… in Pharmaceutical Chemistry Journal (1990)

Article

Synthesis and antiradiation activity of 2-amino-4-oxo-5-amino-methyl(ethyl)thiazolines

A. A. Mandrugin, A. A. Rodyunin, V. M. Fedoseev… in Pharmaceutical Chemistry Journal (1989)