Abstract
We studied the effect of NO synthase inhibitor 2-amino-5,6-dihydro-4H-1,3-thiazine (2-ADT) on the cardiovascular system in rats with endotoxic shock. Blood pressure, heart rate, and respiratory rate were recorded. E. coli lipopolysaccharide decreased blood pressure and heart rate. 2-ADT in a dose of 5 mg/kg normalized these hemodynamic parameters. The normalizing effect of 2-ADT decreased with increasing the dose of this preparation. 2-ADT in high doses (10, 20, and 30 mg/kg) and repeated injections of the preparation caused death of experimental animals.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 10, pp. 446–449, October, 2004
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Proskuryakov, S.Y., Filimonova, M.V., Verkhovskii, Y.G. et al. Effect of NO synthase inhibitor 2-amino-5,6-dihydro-4H-1,3-thiazine on endotoxin-induced changes in hemodynamic parameters and respiration in rats. Bull Exp Biol Med 138, 397–400 (2004). https://doi.org/10.1007/s10517-005-0052-5
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DOI: https://doi.org/10.1007/s10517-005-0052-5