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Article
Open AccessOncogenic CXCL10 signalling drives metastasis development and poor clinical outcome
The CXCL10/CXCR3 signalling mediates paracrine interactions between tumour and stromal cells that govern leukocyte trafficking and angiogenesis. Emerging data implicate noncanonical CXCL10/CXCR3 signalling in ...
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Article
Nfkb1 is a haploinsufficient DNA damage-specific tumor suppressor
NF-κB proteins play a central and subunit-specific role in the response to DNA damage. Previous work identified p50/NF-κB1 as being necessary for cytotoxicity in response to DNA alkylation damage. Given the im...