18 Result(s)

Article

Concordant bone marrow involvement of diffuse large B-cell lymphoma represents a distinct clinical and biological entity in the era of immunotherapy

In diffuse large B-cell lymphoma (DLBCL), the clinical and biological significance of concordant and discordant bone marrow (BM) involvement have not been well investigated. We evaluated 712 de novo DLBCL patient...

Z Yao, L Deng, Z Y Xu-Monette, G C Manyam, P Jain, A Tzankov, C Visco, G Bhagat… in Leukemia (2018)

Article

Loss of PRDM1/BLIMP-1 function contributes to poor prognosis of activated B-cell-like diffuse large B-cell lymphoma

PRDM1/BLIMP-1, a master regulator of plasma-cell differentiation, is frequently inactivated in activated B-cell-like (ABC) diffuse large B-cell lymphoma (DLBCL) patients. Little is known about its genetic aberrat...

Y **a, Z Y Xu-Monette, A Tzankov, X Li, G C Manyam, V Murty, G Bhagat, S Zhang… in Leukemia (2017)

Article

Distinct genetic evolution patterns of relapsing diffuse large B-cell lymphoma revealed by genome-wide copy number aberration and targeted sequencing analysis

Recurrences of diffuse large B-cell lymphomas (DLBCL) result in significant morbidity and mortality, but their underlying genetic and biological mechanisms are unclear. Clonal relationship in DLBCL relapses so...

D Juskevicius, T Lorber, J Gsponer, V Perrina, C Ruiz, F Stenner-Liewen… in Leukemia (2016)

Article

Primary testicular diffuse large B-cell lymphoma displays distinct clinical and biological features for treatment failure in rituximab era: a report from the International PTL Consortium

Primary testicular diffuse large B-cell lymphoma (PT-DLBCL) is a unique subtype of DLBCL. The impact of rituximab on survival and patterns of treatment failure in PT-DLBCL patient remain controversial. We anal...

L Deng, Z Y Xu-Monette, S Loghavi, G C Manyam, Y **a, C Visco, J Huh, L Zhang… in Leukemia (2016)

Article

Numerical impairment of nestin⁺ bone marrow niches in acute GvHD after allogeneic hematopoietic stem cell transplantation for AML

The nestin⁺ perivascular bone marrow (BM) stem cell niche (N⁺SCN) may be involved in GvHD. To investigate whether acute GvHD (aGvHD) reduces the number of N⁺SCN, we examined patients with AML who had undergone al...

M Medinger, W Krenger, A Jakab, J Halter, A Buser, C Bucher… in Bone Marrow Transplantation (2015)

Article

Follicular lymphoma transformation into histiocytic sarcoma: indications for a common neoplastic progenitor

P Brunner, A Rufle, S Dirnhofer, A Lohri, N Willi, G Cathomas, A Tzankov… in Leukemia (2014)

Article

CXCR4-SERINE339 regulates cellular adhesion, retention and mobilization, and is a marker for poor prognosis in acute myeloid leukemia

The CXCR4 receptor is a major regulator of hematopoietic cell migration. Overexpression of CXCR4 has been associated with poor prognosis in acute myelogenous leukemia (AML). We have previously shown that ligan...

L Brault, A Rovó, S Decker, C Dierks, A Tzankov, J Schwaller in Leukemia (2014)

Article

MCL1 is deregulated in subgroups of diffuse large B-cell lymphoma

Myeloid cell leukemia-1 (MCL1) is an anti-apoptotic member of the BCL2 family that is deregulated in various solid and hematological malignancies. However, its role in the molecular pathogenesis of diffuse lar...

S-S Wenzel, M Grau, C Mavis, S Hailfinger, A Wolf, H Madle, G Deeb, B Dörken… in Leukemia (2013)

Article

GVHD after allogeneic haematopoietic SCT for AML: angiogenesis, vascular endothelial growth factor and VEGF receptor expression in the BM

There is increasing evidence suggesting that both angiogenesis and endothelial injury are involved in GVHD. To study the dynamics of angiogenesis, we examined 26 patients with AML who had undergone allogeneic ...

M Medinger, A Tichelli, C Bucher, J Halter, S Dirnhofer… in Bone Marrow Transplantation (2013)

Article

Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf

Proapoptotic Bcl-2 family members of the Bcl-2 homology (BH)3-only subgroup are critical for the establishment and maintenance of tissue homeostasis and can mediate apoptotic cell death in response to developm...

F Baumgartner, C Woess, V Pedit, A Tzankov, V Labi, A Villunger in Oncogene (2013)

Article

Systemic microRNA-34a delivery induces apoptosis and abrogates growth of diffuse large B-cell lymphoma in vivo

V J Craig, A Tzankov, M Flori, C A Schmid, A G Bader, A Müller in Leukemia (2012)

Article

Comprehensive gene expression profiling and immunohistochemical studies support application of immunophenotypic algorithm for molecular subtype classification in diffuse large B-cell lymphoma: a report from the International DLBCL Rituximab-CHOP Consortium Program Study

Gene expression profiling (GEP) has stratified diffuse large B-cell lymphoma (DLBCL) into molecular subgroups that correspond to different stages of lymphocyte development–namely germinal center B-cell like an...

C Visco, Y Li, Z Y Xu-Monette, R N Miranda, T M Green, Y Li, A Tzankov, W Wen… in Leukemia (2012)

Article

Consideration of exposure to pharmacological agents helps to avoid diagnostic pitfalls in bone marrow histopathology

Trephine bone marrow biopsy is a frequent routine investigation, particularly important in cases with an unsuccessful aspirate. In addition to a representative trephine biopsy length and quality, the patient's...

S. Hoeller, A. Tzankov in memo - Magazine of European Medical Oncology (2010)

Article

Targetable oncogenic pathways in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma

Classical Hodgkin lymphoma is a lymphoid neoplasm consisting of mononuclear Hodgkin and multinuclear Reed-Sternberg cells, mostly of B-cell origin, embedded in a non-neoplastic background. Most patients are cu...

A. Tzankov in memo - Magazine of European Medical Oncology (2008)

Article

The JAK2 V617F mutation occurs frequently in myelodysplastic/myeloproliferative diseases, but is absent in true myelodysplastic syndromes with fibrosis

M Kremer, T Horn, T Dechow, A Tzankov, L Quintanilla-Martínez, F Fend in Leukemia (2006)