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Article
Open AccessCDK9 inhibition as an effective therapy for small cell lung cancer
Treatment-naïve small cell lung cancer (SCLC) is typically susceptible to standard-of-care chemotherapy consisting of cisplatin and etoposide recently combined with PD-L1 inhibitors. Yet, in most cases, SCLC p...
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Article
Open AccessMesoscopic Klein-Schwinger effect in graphene
Strong electric field annihilation by particle–antiparticle pair creation, also known as the Schwinger effect, is a non-perturbative prediction of quantum electrodynamics. Its experimental demonstration remain...
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Article
Systemic relapses of primary CNS lymphomas (PCNSL): a LOC network study
Primary central nervous system lymphomas (PCNSLs) classically remain confined within the CNS throughout their evolution for unknown reasons. Our objective was to analyse the rare extracerebral relapses of PCNS...
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Article
Open AccessPredictors and outcomes in primary depression care (POKAL) – a research training group develops an innovative approach to collaborative care
The interdisciplinary research training group (POKAL) aims to improve care for patients with depression and multimorbidity in primary care.
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Article
Open AccessStandardized evaluation of the quality and persuasiveness of mobile health applications for diabetes management
This study evaluates diabetes self-management mobile health applications available from European app stores with respect to quality, concordance with recommended self-management tasks and implementation of per...
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Article
Open AccessModulation of cognition and neuronal plasticity in gain- and loss-of-function mouse models of the schizophrenia risk gene Tcf4
The transcription factor TCF4 was confirmed in several large genome-wide association studies as one of the most significant schizophrenia (SZ) susceptibility genes. Transgenic mice moderately overexpressing Tcf4 ...
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Chapter and Conference Paper
3D-Reconstruction and Semantic Segmentation of Cystoscopic Images
Bladder cancer (BCa) is the fourth most common cancer and the eighth most common cause of cancer-related mortality in men. Although roughly 75% of patients are diagnosed with non-muscle invasive bladder cancer...
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Article
Diagnostik und Therapie der chronischen patellofemoralen Instabilität
Die chronische patellofemorale Instabilität ist ein multifaktorielles und häufig angeborenes Krankheitsbild. Die Luxation der Patella erfolgt hierbei meist atraumatisch. Eine rein konservative Therapie ist zum...
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Article
Diagnostik und Therapie der chronischen patellofemoralen Instabilität
Die chronische patellofemorale Instabilität ist ein multifaktorielles und häufig angeborenes Krankheitsbild. Die Luxation der Patella erfolgt hierbei meist atraumatisch. Eine rein konservative Therapie ist zum...
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Article
(R)-GEMOX chemotherapy for unfit patients with refractory or recurrent primary central nervous system lymphoma: a LOC study
Recurrent primary central nervous system lymphomas (PCNSL) have a very poor prognosis. For young and fit patients, intensive chemotherapy followed by autologous stem cell transplantation could be proposed at r...
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Article
Refixation tibialer knöcherner Avulsionsverletzungen des hinteren Kreuzbandes in Fadenankertechnik
Anatomische Refixation knöcherner tibialer Avulsionsverletzungen des hinteren Kreuzbandes (HKB) mit SutureBridge™-Technik (Arthrex, Naples, FL, USA) zur Wiederherstellung der posterioren Kniegelenkstabilität.
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Article
Akute Verletzung des hinteren Kreuzbandes mit femoraler Avulsion
Wiederherstellung der anatomischen und biomechanischen Eigenschaften des hinteren Kreuzbandes (HKB) in der Akutsituation. Hierbei erfolgt die arthroskopisch gestützte Reinsertion des HKB durch Auszugsnähte kom...
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Article
Degenerative isolated cartilage defects of the patellofemoral joint are associated with more severe symptoms compared to trauma-related defects: results of the German Cartilage Registry (KnorpelRegister DGOU)
The purpose of this study was to utilize data from the German Cartilage Registry (KnorpelRegister DGOU) to examine the hypothesis that degenerative cartilage defects of the patellofemoral joint are associated ...
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Article
A numerical study of a semi-Lagrangian Parareal method applied to the viscous Burgers equation
This work focuses on the Parareal parallel-in-time method and its application to the viscous Burgers equation. A crucial component of Parareal is the coarse time step** scheme, which strongly impacts the con...
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Article
Parese des Plexus brachialis nach vorderer Schulterluxation
Nach traumatischer vorderer Schulterluxation mit Eigenreposition bot ein Patient bis auf eine schmerzhafte Bewegungseinschränkung zunächst einen unauffälligen klinischen Verlauf. In der chirurgischen Notaufnah...
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Article
Open AccessOptimized protocol for whole organ decellularization
The idea of tissue decellularization to gain matrices for tissue engineering is promising. The aim of the present study is to establish a safe and reproducible protocol for solid tissue decellularization that ...
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Article
Ligament-Bracing des hinteren Kreuzbands
Das Ziel des arthroskopischen Bracings ist die Wiederherstellung der Kniegelenkstabilität durch die primäre Augmentation mittels eines stabilen Fadenzugsystems.
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Article
Open AccessPolygenic risk has an impact on the structural plasticity of hippocampal subfields during aerobic exercise combined with cognitive remediation in multi-episode schizophrenia
Preliminary studies suggest that, besides improving cognition, aerobic exercise might increase hippocampal volume in schizophrenia patients; however, results are not consistent. Individual mechanisms of volume...
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Article
Retour d’expériences sur l’étude de trois assemblages osseux issus de sépultures collectives néolithiques
La plupart des sépultures collectives du Néolithique final ayant bénéficié de fouilles et d’un enregistrement optimaux ont livré une grande quantité d’ossements. Le croisement des données archéologiques et ant...
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Article
Extracellular vesicle-transported Semaphorin3A promotes vascular permeability in glioblastoma
Glioblastoma are malignant highly vascularized brain tumours, which feature large oedema resulting from tumour-promoted vascular leakage. The pro-permeability factor Semaphorin3A (Sema3A) produced within gliob...
