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Article
Zur Frage des Blutzuckerspiegels bei Infektionskrankheiten
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Article
Wirkungen eines adrenergischen Beta-Receptorenblockers (Kö592) auf die Atmung
Die Wirkung von 1-(Isopropylamino)-3-(m-tolyloxy)-2-propanol, hydrochlorid (Versuchsbezeichnung Kö 592) auf die ventilatorische Funktion von 8 Gesunden, 12 Asthmatikern und 19 Bronchitikern wurde spirographisc...
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Article
Chronic hepatic prophyria type C
In four patients with liver disease (fatty liver, fibrosis, and cirrhosis) the concentrations of uroporphyrin and heptacarboxylic porphyrin in the liver were found to be considerably elevated (up to 90 µg/g). ...
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Article
Hepatic porphyrins and urinary prophyrins and prophyrin precursors in liver cirrhosis
In 21 liver cirrhotics (19 men, 2 women) the urinary excretion ofδ-aminolevulinic acid, porphobilinogen, uro- and coproporphyrin, and hepta-, hexa-, and pentacarboxylic porphyrin was studied. Porphyrins in liver ...
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Article
Diamine oxidases in the small intestine of rabbits, dogs and pigs: Separation from soluble monoamine oxidases and substrate specificity of the enzymes
The high potency of the small intestine to inactivate vasoactive biogenic amines is a combined effect of diamine and monoamine oxidase activity. Histamine, however, is specifically deaminated by diamine oxidase.
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Article
Serumlysozym-Konzentrationen bei Patienten Mit Morbus Crohn vor und nach Darmresektion
Serum lysozyme (muramidase) concentrations were determined in five patients with Morbus Crohn before and after resection of inflammated bowel areas. The serum lysozyme activity which was elevated before surgic...
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Article
Diamine oxidase activity in gastric and duodenal mucosa of man and other mammals with special reference to the pyloric junction
In the gastric mucosa of human subjects and of various mammals methylation was accepted as the main pathway of histamine catabolism. However, augmentation of gastric acid secretion by aminoguanidine, the stron...
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Article
The genetic significance of accessory bisatellited marker chromosomes
Ten new cases of accessory bisatellited marker chromosomes examined in different laboratories are reported. As a basis for genetic counselling in the context of prenatal diagnosis a cytogenetic categorization ...
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Article
Recurrent mutation pressure does not explain the prevalence of the marker (X) syndrome
In order to test the hypothesis that the high prevalence of the mar(X) syndrome is caused by a high mutation rate in male germ cells only, the fraction of new mutants among mothers of probands in 112 informati...
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Article
Right ventricular function in patients with chronic obstructive pulmonary disease
Simultaneous right heart catheterization and radionuclide ventriculography were performed in 27 patients with a wide range of chronic obstructive pulmonary disease. Central hemodynamics and radionuclide studie...
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Article
Behandlung mit Mexiletin
Pharmacokinetics of the antiarrhythmic agent mexiletine were found to be highly variable. Ineffective or toxic doses can be avoided by monitoring mexiletine concentrations in patients plasma. However, the succ...
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Article
Belastungsuntersuchung bei langjährigem Typ-I-Diabetes mit der Radionuklidventrikulographie
Left ventricular function was assessed by means of radionuclide ventriculography in 42 patients with long-standing (13±5 yrs) insulin-dependent diabetes mellitus and in eleven healthy age matched control subje...
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Article
Hemodynamic profile of carvedilol
Several so-called multiple-action compounds have been developed, such as medroxalol (alpha and beta blockade, and beta-2 stimulation), celiprolol (alpha-2 and beta-1 blockade, and beta-2 stimulation) and carve...
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Article
Neurological outcome after a severe herpes simplex encephalitis treated with acyclovir and β-interferon time course of intracranial pressure
A severe herpes simplex encephalitis with documented intra-cerebral lesions and brain edema was treated successfully with acyclovir andβ-interferon. The increase in intracranial pressure during the second week wa...
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Article
Effect of respiratory training with a mouth-nose-mask in tetraplegics
Ten tetraplegics, 8 males and 2 females, with a median age of 32 years participated in a scheduled 6 weeks training programme with a respiratory muscle training mouth-nose-mask (RMT-mask) with a fixed expirato...
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Article
Molecular analysis of mutations in the gene FMR-1 segregating in fragile X families
Molecular genetic analysis of the transmission of mutations in 73 families with fragile X (one of the largest samples evaluated so far) has confirmed previous hypotheses that the fragile X syndrome results fro...
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Article
Cognitive and motor deficits associated with HIV-2287 infection in infant pigtailed macaques: A nonhuman primate model of pediatric neuro-AIDS
Lentivirus-infected nonhuman primates exhibit behavioral and neurological pathology similar to human immunodeficiency virus (HIV)-infected humans and offer a means to examine the effects of lentivirus infectio...
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Vector Technology and Cell Targeting: Peptide-Tagged Adenoviral Vectors as a Powerful Tool for Cell Specific Targeting
A pre-requisite for efficient and successful treatment of diseases consists in the development of technologies which yield the transfer of therapeutic genes and drugs exclusively to target cells by avoiding t...
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Article
Evaluation of systemic targeting of RET oncogene-based MTC with tumor-selective peptide-tagged Ad vectors in clinical mouse models
Significant advantage of targeted antitumoral treatment consists in the possibility to restrict maximum therapeutic efficacy to the malignant cell population by reducing toxicity in healthy tissues. Using diff...