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1,113 Result(s)
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Article
Open AccessBibliometric and visual analysis in the field of two-dimensions nano black phosphorus in cancer from 2015 to 2023
This study aims to provide a comprehensive summary of the status and trends of Two-Dimensional Nano Black Phosphorus (2D nano BP) in cancer research from 2015 to 2023, offering insights for future studies. To ...
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Tracking-seq reveals the heterogeneity of off-target effects in CRISPR–Cas9-mediated genome editing
The continued development of novel genome editors calls for a universal method to analyze their off-target effects. Here we describe a versatile method, called Tracking-seq, for in situ identification of off-t...
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Open AccessPrognostic significance of hemoglobin, albumin, lymphocyte, and platelet (HALP) score in breast cancer: a propensity score-matching study
The hemoglobin-albumin-lymphocyte-platelet (HALP) score functions as a comprehensive index that assesses the systemic inflammatory response, nutritional, and immune status. This study aimed to explore the rela...
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E-DBRL: efficient double broad reinforcement learning for adaptive traffic signal control
Efficient traffic signal management is crucial for regulating traffic flow and fostering sustainable development within road transportation systems. To address the challenges in traffic management, numerous st...
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Open AccessEffects of Staphylococcus aureus on stem cells and potential targeted treatment of inflammatory disorders
Due to the advanced studies on stem cells in developmental biology, the roles of stem cells in the body and their phenotypes in related diseases have not been covered clearly. Meanwhile, with the intensive res...
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Open AccessAnalysis of tumor microenvironment alterations in partially responsive rectal cancer patients treated with neoadjuvant chemoradiotherapy
Achieving a pathologic complete response (pCR) after neoadjuvant chemoradiotherapy (NCRT) remains a challenge for most patients with rectal cancer. Exploring the potential of combining NCRT with immunotherapy ...
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Open AccessU-shaped association between triglyceride-glucose index and all-cause mortality among critically ill pediatrics: a population-based retrospective cohort study
Previous studies have shown that an elevated triglyceride-glucose (TyG) index was associated with all-cause mortality in both general adult individuals and critically ill adult patients. However, the relations...
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Open AccessEmerging roles of ferroptosis in pulmonary fibrosis: current perspectives, opportunities and challenges
Pulmonary fibrosis (PF) is a chronic interstitial lung disorder characterized by abnormal myofibroblast activation, accumulation of extracellular matrix (ECM), and thickening of fibrotic alveolar walls, result...
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Hydrogen Sulfide can Scavenge Free Radicals to Improve Spinal Cord Injury by Inhibiting the p38MAPK/mTOR/NF-κB Signaling Pathway
Spinal cord injury (SCI) causes irreversible cell loss and neurological dysfunctions. Presently, there is no an effective clinical treatment for SCI. It can be the only intervention measure by relieving the sy...
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Open AccessHippocampal and orbitofrontal neurons contribute to complementary aspects of associative structure
The ability to establish associations between environmental stimuli is fundamental for higher-order brain functions like state inference and generalization. Both the hippocampus and orbitofrontal cortex (OFC) ...
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Open AccessTumor initiation and early tumorigenesis: molecular mechanisms and interventional targets
Tumorigenesis is a multistep process, with oncogenic mutations in a normal cell conferring clonal advantage as the initial event. However, despite pervasive somatic mutations and clonal expansion in normal tis...
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Brief mindfulness intervention attenuates self-serving bias rather than boosts self-enhancement
The relationship between mindfulness and self-enhancement has been a topic of debate in recent years. While some researchers have found that mindfulness practitioners exhibit higher levels of self-enhancement ...
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Open AccessInfluence of protective clothing and masks on facial trustworthiness in an investment game: insights from a Chinese population study
Facial features are important sources of information about perceived trustworthiness. Masks and protective clothing diminish the visibility of facial cues by either partially concealing the mouth and nose or c...
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Open AccessAberrant expression of B7-H4 and B7-H5 contributes to the development of cutaneous squamous cell carcinoma
Cutaneous squamous cell carcinoma (CSCC) is the second most common malignant tumor of the skin. B7 homolog 4 (B7-H4) and B7-H5 (B7 homolog 5) are associated with a variety of tumors. Investigate the potential ...
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Pathogenesis-Related Protein 10 Family Genes Involved in Sugarcane Responses to Biotic Stressors and Salicylic Acid
Pathogenesis-related protein 10 (PR10) family genes play a crucial role in plant defense against various stressors. However, gene member and function identification of PR10 family in sugarcane remain largely u...
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ASO Visual Abstract: Long-Term Outcomes of Orthotopic Neobladder versus Ileal Conduit Urinary Diversion in Robot-Assisted Radical Cystectomy (RARC): Multicenter Results from the Asian RARC Consortium
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Advancements of Macrophages Involvement in Pathological Progression of Colitis-Associated Colorectal Cancer and Associated Pharmacological Interventions
Intestinal macrophages play crucial roles in both intestinal inflammation and immune homeostasis. They can adopt two distinct phenotypes, primarily determined by environmental cues. These phenotypes encompass ...
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Article
DMF-scMT-seq linking methylome and transcriptome within single cells with digital microfluidics
Single-cell joint analysis of methylome and transcriptome reveals how the methylation regulates the transcriptional activity. However, traditional bench-top protocols for single-cell DNA methylation and RNA tr...
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Cell-specific localization of β-synuclein in the mouse retina
β-synuclein, a member of the synuclein family, is frequently co-expressed with α-synuclein in the neural system, where it serves to inhibit abnormal aggregation of α-synuclein in neurodegenerative diseases. Be...