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Open AccessClinical associations with a polygenic predisposition to benign lower white blood cell counts
Polygenic variation unrelated to disease contributes to interindividual variation in baseline white blood cell (WBC) counts, but its clinical significance is uncharacterized. We investigated the clinical conse...
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Open AccessNortriptyline hydrochloride, a potential candidate for drug repurposing, inhibits gastric cancer by inducing oxidative stress by triggering the Keap1-Nrf2 pathway
Effective drugs for the treatment of gastric cancer (GC) are still lacking. Nortriptyline Hydrochloride (NTP), a commonly used antidepressant medication, has been demonstrated by numerous studies to have antit...
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Article
Open AccessTherapy effect of cochleural alternating acoustic beam therapy versus traditional sound therapy for managing chronic idiopathic tinnitus patients
Idiopathic tinnitus is a common and complex disorder with no established cure. The CAABT (Cochleural Alternating Acoustic Beam Therapy CAABT), is a personalized sound therapy designed to target specific tinnit...
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Article
Open AccessSentiment analysis of video danmakus based on MIBE-RoBERTa-FF-BiLSTM
Danmakus are user-generated comments that overlay on videos, enabling real-time interactions between viewers and video content. The emotional orientation of danmakus can reflect the attitudes and opinions of v...
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Open AccessContribution of uniparental disomy to fetal growth restriction: a whole-exome sequencing series in a prenatal setting
Fetal growth restriction (FGR), a leading cause of perinatal morbidity and mortality, is caused by fetal, maternal, and placental factors. Uniparental disomy (UPD) is a rare condition that leads to imprinting ...
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Open AccessStrong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease
African Americans have a significantly higher risk of develo** chronic kidney disease, especially focal segmental glomerulosclerosis -, than European Americans. Two coding variants (G1 and G2) in the APOL1 gene...
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Open AccessProjecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms
Genes act in concert with each other in specific contexts to perform their functions. Determining how these genes influence complex traits requires a mechanistic understanding of expression regulation across d...
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Open AccessPrediction model and demonstration of regional agricultural carbon emissions based on Isomap–ACO–ET: a case study of Guangdong Province, China
Scientific analysis of regional agricultural carbon emission prediction models and empirical studies are of great practical significance to the realization of low-carbon agriculture, which can help revitalize ...
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Open AccessDiscovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection
The SARS-CoV-2 Omicron variant evades most currently approved neutralizing antibodies (nAbs) and caused drastic decrease of plasma neutralizing activity elicited by vaccination or prior infection, urging the n...
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Author Correction: The power of genetic diversity in genome-wide association studies of lipids
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Open AccessEnzymatic polymerization of enantiomeric L−3,4-dihydroxyphenylalanine into films with enhanced rigidity and stability
L−3,4-dihydroxyphenylalanine is an important molecule in the adhesion of mussels, and as an oxidative precursor of natural melanin, it plays an important role in living system. Here, we investigate the effect o.....
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Open AccessValorization of rice straw, sugarcane bagasse and sweet sorghum bagasse for the production of bioethanol and phenylacetylcarbinol
Open burning of agricultural residues causes numerous complications including particulate matter pollution in the air, soil degradation, global warming and many more. Since they possess bio-conversion potentia...
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Open AccessSirtuin 6 maintains epithelial STAT6 activity to support intestinal tuft cell development and type 2 immunity
Dynamic regulation of intestinal epithelial cell (IEC) differentiation is crucial for both homeostasis and the response to helminth infection. SIRT6 belongs to the NAD+-dependent deacetylases and has established ...
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Open AccessNatural variation of DROT1 confers drought adaptation in upland rice
Upland rice is a distinct ecotype that grows in aerobic environments and tolerates drought stress. However, the genetic basis of its drought resistance is unclear. Here, using an integrative approach combining...
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Open AccessEffects of modified atmosphere packaging on the postharvest quality of mulberry leaf vegetable
Fresh mulberry leaf vegetable is nutritive and becoming popular. However, available preservation technologies are deficient. In present work, the effects of two kinds of modified atmosphere packaging on postha...
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Open AccessLarge-scale genomic analyses reveal insights into pleiotropy across circulatory system diseases and nervous system disorders
Clinical and epidemiological studies have shown that circulatory system diseases and nervous system disorders often co-occur in patients. However, genetic susceptibility factors shared between these disease ca...
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Open AccessGlobal impacts of future urban expansion on terrestrial vertebrate diversity
Rapid urban expansion has profound impacts on global biodiversity through habitat conversion, degradation, fragmentation, and species extinction. However, how future urban expansion will affect global biodiver...
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Open AccessGlobal monthly gridded atmospheric carbon dioxide concentrations under the historical and future scenarios
Increases in atmospheric carbon dioxide (CO2) concentrations is the main driver of global warming due to fossil fuel combustion. Satellite observations provide continuous global CO2 retrieval products, that revea...
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Open AccessIntegrating gene expression and clinical data to identify drug repurposing candidates for hyperlipidemia and hypertension
Discovering novel uses for existing drugs, through drug repurposing, can reduce the time, costs, and risk of failure associated with new drug development. However, prioritizing drug repurposing candidates for ...
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Open AccessAn updated, computable MEDication-Indication resource for biomedical research
The MEDication-Indication (MEDI) knowledgebase has been utilized in research with electronic health records (EHRs) since its publication in 2013. To account for new drugs and terminology updates, we rebuilt ME...