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Article
Open AccessAnalysis of the multiple drivers of vegetation cover evolution in the Taihangshan-Yanshan region
The Taihangshan-Yanshan region (TYR) is an important ecological barrier area for Bei**g-Tian**-Hebei, and the effectiveness of its ecological restoration and protection is of great significance to the ecolog...
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Article
Open AccessStructure and genome editing of type I-B CRISPR-Cas
Type I CRISPR-Cas systems employ multi-subunit effector Cascade and helicase-nuclease Cas3 to target and degrade foreign nucleic acids, representing the most abundant RNA-guided adaptive immune systems in prok...
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Article
Open AccessSpontaneous crystallization of strongly confined CsSnxPb1-xI3 perovskite colloidal quantum dots at room temperature
The scalable and low-cost room temperature (RT) synthesis for pure-iodine all-inorganic perovskite colloidal quantum dots (QDs) is a challenge due to the phase transition induced by thermal unequilibrium. Here...
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Article
Open AccessResNet incorporating the fusion data of RGB & hyperspectral images improves classification accuracy of vegetable soybean freshness
The freshness of vegetable soybean (VS) is an important indicator for quality evaluation. Currently, deep learning-based image recognition technology provides a fast, efficient, and low-cost method for analyzi...
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Article
Open AccessPrediction of nonlayered oxide monolayers as flexible high-κ dielectrics with negative Poisson’s ratios
During the last two decades, two-dimensional (2D) materials have been the focus of condensed matter physics and material science due to their promising fundamental properties and (opto-)electronic applications...
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Open AccessDeconvolution reveals cell-type-specific transcriptomic changes in the aging mouse brain
Mounting evidence highlights the crucial role of aging in the pathogenesis of Alzheimer's disease (AD). We have previously explored human apoE-targeted replacement mice across different ages and identified dis...
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Article
Open AccessA comprehensive genomic catalog from global cold seeps
Cold seeps harbor abundant and diverse microbes with tremendous potential for biological applications and that have a significant influence on biogeochemical cycles. Although recent metagenomic studies have ex...
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Article
Open AccessUncovering spin-orbit coupling-independent hidden spin polarization of energy bands in antiferromagnets
Many textbook physical effects in crystals are enabled by some specific symmetries. In contrast to such ‘apparent effects’, ‘hidden effect X’ refers to the general condition where the nominal global system sym...
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Article
Open AccessPhylogenetically and catabolically diverse diazotrophs reside in deep-sea cold seep sediments
Microbially mediated nitrogen cycling in carbon-dominated cold seep environments remains poorly understood. So far anaerobic methanotrophic archaea (ANME-2) and their sulfate-reducing bacterial partners (SEEP-...
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Article
Open AccessUSP14-regulated allostery of the human proteasome by time-resolved cryo-EM
Proteasomal degradation of ubiquitylated proteins is tightly regulated at multiple levels1–3. A primary regulatory checkpoint is the removal of ubiquitin chains from substrates by the deubiquitylating enzyme ubiq...
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Article
Open AccessAdaptations of Interferon Regulatory Factor 3 with Transition from Terrestrial to Aquatic Life
Interferon regulatory factor 3 (IRF3) and IRF7 are closely related IRF members and the major factors for the induction of interferons, a key component in vertebrate innate immunity. However, there is limited k...
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Article
Open AccessVapor Cannabis Exposure Promotes Genetic Plasticity in the Rat Hypothalamus
It is well established that cannabis use promotes appetite. However, how cannabis interacts with the brain’s appetite center, the hypothalamus, to stimulate feeding behavior is unknown. A growing body of evide...
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Article
Open AccessTwo-dimensional inorganic molecular crystals
Two-dimensional molecular crystals, consisting of zero-dimensional molecules, are very appealing due to their novel physical properties. However, they are mostly limited to organic molecules. The synthesis of ...
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Article
Open AccessVolumetric optoacoustic tomography enables non-invasive in vivo characterization of impaired heart function in hypoxic conditions
Exposure to chronic hypoxia results in pulmonary hypertension characterized by increased vascular resistance and pulmonary vascular remodeling, changes in functional parameters of the pulmonary vasculature, an...
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Article
Open AccessMitogenomics of historical type specimens of Australasian turtles: clarification of taxonomic confusion and old mitochondrial introgression
Diagnosability is central to taxonomy as are type specimens which define taxa. New advances in technologies and the discovery of new informative traits must be matched with previous taxonomic decisions based o...
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Article
Open AccessLand Surface Temperature Response to Irrigated Paddy Field Expansion: a Case Study of Semi-arid Western Jilin Province, China
The irrigated paddy fields have expanded greatly at semi-arid western Jilin province of China in recent over ten years, the sources of which are rain-fed cornfields, swamp meadow and saline alkali land mainly....
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Article
Open AccessUncovering and tailoring hidden Rashba spin–orbit splitting in centrosymmetric crystals
Hidden Rashba and Dresselhaus spin splittings in centrosymmetric crystals with subunits/sectors having non-centrosymmetric symmetries (the R-2 and D-2 effects) have been predicted theoretically and then observ...
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Article
Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome
The proteasome is an ATP-dependent, 2.5-megadalton molecular machine that is responsible for selective protein degradation in eukaryotic cells. Here we present cryo-electron microscopy structures of the substr...
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Open AccessAlternative polyadenylation drives genome-to-phenome information detours in the AMPKα1 and AMPKα2 knockout mice
Currently available mouse knockout (KO) lines remain largely uncharacterized for genome-to-phenome (G2P) information flows. Here we test our hypothesis that altered myogenesis seen in AMPKα1- and AMPKα2-KO mic...
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Article
Open AccessInteratomic Potentials Transferability for Molecular Simulations: A Comparative Study for Platinum, Gold and Silver
A perfectly transferable interatomic potential that works for different materials and systems of interest is lacking. This work considers the transferability of several existing interatomic potentials by evalu...