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1,313 Result(s)
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Erratum: The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1
Correction to: Oncogene (2002) 21, 1381–1390. DOI: 10.1038/sj.onc.1205192 The authors wish to apologise for an error found in the discussion section. A revised version of the text is given below: Moreover, alt...
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Correction: Overexpression of the thymosin beta-10 gene in human ovarian cancer cells disrupts F-actin stress fiber and leads to apoptosis
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Erratum: Expression of activated M-Ras in a murine mammary epithelial cell line induces epithelial–mesenchymal transition and tumorigenesis
Correction to: Oncogene (2004) 23, 1187–1196. doi:10.1038/sj.onc.1207226 Owing to a typesetting error, the second author name was spelled incorrectly. The correct spelling is Kai-**n Zhang.
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Erratum: TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin
Elena A Feshchenko1,4, Evgeniya V Smirnova1, Gayathri Swaminathan1, Anjali M Teckchandani1, Rachana Agrawal1, Hamid Band2,5, **aolong Zhang3,6, Roland S Annan3, Steven A Carr3,7, Alexander Y Tsygankov*,1 Corre...
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Erratum: Ski can negatively regulates macrophage differentiation through its interaction with PU.1
Correction to: Oncogene (2008) 27, 300–307; doi:10.1038/sj.onc.1210654; published online 9 July 2007 Due to a typesetting error, the name of the third author was misspelt. The corrected author list is shown ab...
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Erratum: EMX2 is epigenetically silenced and suppresses growth in human lung cancer
Correction to: Oncogene (2010) 29, 5969–5975; doi:10.1038/onc.2010.330; published online 9 August 2010 Since the publication of the above manuscript, the authors have identified an error in the author list; th...
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Open AccessLoss of a single Hic1 allele accelerates polyp formation in ApcΔ716 mice
Adenomatous polyposis coli (APC) gene mutations have been implicated in familial and sporadic gastrointestinal (GI) cancers. APC mutations are associated with autosomal dominant inheritance of disease in humans. ...
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Open AccessEts-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress
Past studies have shown that upregulation of the anti-apoptotic Bcl-2 family protein Mcl-1 is a major adaptive mechanism of melanoma cells to endoplasmic reticulum (ER) stress, and has an important role in res...
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Open AccessNephroblastoma overexpressed (NOV/CCN3) gene: a paired-domain-specific PAX3-FKHR transcription target that promotes survival and motility in alveolar rhabdomyosarcoma cells
The CCN (Cy61, CTGF and NOV) family of proteins is a group of matricellular biomolecules involved in both physiological and pathological processes. Elevated expression of the CCN3 (also known as NOV, Nephroblasto...
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Retraction Note: Requirement for chromatin-remodeling complex in novel tumor suppressor HIC1-mediated transcriptional repression and growth control
The authors wish to retract this article after examination of the publication raised concerns that the primary real-time PCR data, which underlie several of the figures in the article, may not be accurate.
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Article
Open AccessFZD7 has a critical role in cell proliferation in triple negative breast cancer
Breast cancer is genetically and clinically heterogeneous. Triple negative breast cancer (TNBC) is a subtype of breast cancer that is usually associated with poor outcome and lack of benefit from targeted ther...
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Open AccessIRX1 influences peritoneal spreading and metastasis via inhibiting BDKRB2-dependent neovascularization on gastric cancer
The overexpression of IRX1 gene correlates with the growth arrest in gastric cancer. Furthermore, overexpression of IRX1 gene suppresses peritoneal spreading and long distance metastasis. To explore the precise m...
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Open AccessMiR-100 regulates cell differentiation and survival by targeting RBSP3, a phosphatase-like tumor suppressor in acute myeloid leukemia
Acute myeloblastic leukemia (AML) is characterized by the accumulation of abnormal myeloblasts (mainly granulocyte or monocyte precursors) in the bone marrow and blood. Though great progress has been made for ...
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Open AccessMicroRNA-335 acts as a metastasis suppressor in gastric cancer by targeting Bcl-w and specificity protein 1
Aberrant expression of miR-335 has been frequently reported in cancer studies, suggesting that there is a close correlation between miR-335 and cancer during its development, progression, metastasis and progno...
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Open AccessThe human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt/β-catenin signaling and silenced in common carcinomas
Genetic alterations of 16q21-q22, the locus of a 6-cadherin cluster, are frequently involved in multiple tumors, suggesting the presence of critical tumor suppressor genes (TSGs). Using 1 Mb array comparative ...
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Open AccessMicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-κB and TGF-β signaling pathways
MicroRNAs (miRNAs) as modulators of gene expression have been described to display both tumor-promoting and tumor-suppressive functions. Although their role has been studied in different tumor types, little is...
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Erratum: Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness
Correction to: Oncogene (2010) 29, 2916–2926; doi:10.1038/onc.2010.62; published online 8 March 2010 Following the publication of this manuscript1 we obtained new information, including corrected DNA fingerpri...
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Open AccessConditional activation of Pik3caH1047R in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations
Oncogenic mutations in PIK3CA, which encodes the phosphoinositide-3-kinase (PI3K) catalytic subunit p110α, occur in ∼25% of human breast cancers. In this study, we report the development of a knock-in mouse model...
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Open AccessRe-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer
Epithelial–mesenchymal transition (EMT) is an initiating event in tumor cell invasion and metastasis. It has been shown to occur in resistance to a range of cancer therapies, including tamoxifen. MicroRNAs (mi...
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Open AccessMicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer
Past studies have shown that amplified insulin-like growth factor 1 (IGF1)/IGF1 receptor (IGF1-R) signalling has an important role in colorectal cancer (CRC) development, progression and resistance to treatmen...