766 Result(s)

Article

A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori

Helicobacter pylori (H. pylori) is currently recognized as the primary carcinogenic pathogen associated with gastric tumorigenesis, and its high prevalence and resistance make it difficult to tackle. A graph neur...

**xi Guo, **aosa Zhao, ** Lu, Li** Zhao… in Signal Transduction and Targeted Therapy (2024)

Article

Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression

More than 90% of hepatocellular carcinoma (HCC) cases develop in the presence of fibrosis or cirrhosis, making the tumor microenvironment (TME) of HCC distinctive due to the intricate interplay between cancer-...

Hao Peng, Meng Yang, Kun Feng, Qingpeng Lv… in Signal Transduction and Targeted Therapy (2024)

Article

A Cullin 5-based complex serves as an essential modulator of ORF9b stability in SARS-CoV-2 replication

The ORF9b protein, derived from the nucleocapsid’s open-reading frame in both SARS-CoV and SARS-CoV-2, serves as an accessory protein crucial for viral immune evasion by inhibiting the innate immune response. ...

Yuzheng Zhou, Zongpeng Chen, Sijie Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Clinical efficacy and identification of factors confer resistance to afatinib (tyrosine kinase inhibitor) in EGFR-overexpressing esophageal squamous cell carcinoma

Epidermal growth factor receptor (EGFR) is reportedly overexpressed in most esophageal squamous cell carcinoma (ESCC) patients, but anti-EGFR treatments offer limited survival benefits. Our preclinical data sh...

Yanni Wang, Chang Liu, Huan Chen, ** Jiao… in Signal Transduction and Targeted Therapy (2024)

Article

Targeting a disintegrin and metalloprotease (ADAM) 17-CD122 axis enhances CD8⁺ T cell effector differentiation and anti-tumor immunity

CD8⁺ T cell immune responses are regulated by multi-layer networks, while the post-translational regulation remains largely unknown. Transmembrane ectodomain shedding is an important post-translational process or...

Lina Sun, Anjun Jiao, Haiyan Liu, Renyi Ding… in Signal Transduction and Targeted Therapy (2024)

Article

Engineered extracellular vesicles for targeted reprogramming of cancer-associated fibroblasts to potentiate therapy of pancreatic cancer

Pancreatic cancer is one of the deadly malignancies with a significant mortality rate and there are currently few therapeutic options for it. The tumor microenvironment (TME) in pancreatic cancer, distinguishe...

Pengcheng Zhou, Xuanlong Du, Weilu Jia… in Signal Transduction and Targeted Therapy (2024)

Article

Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets

Tumorigenesis is a multistep process, with oncogenic mutations in a normal cell conferring clonal advantage as the initial event. However, despite pervasive somatic mutations and clonal expansion in normal tis...

Shaosen Zhang, **nyi **ao, Yonglin Yi… in Signal Transduction and Targeted Therapy (2024)

Article

Neoadjuvant camrelizumab (an anti-PD-1 antibody) plus chemotherapy or apatinib (a VEGFR-2 inhibitor) for initially unresectable stage II–III non-small-cell lung cancer: a multicentre, two-arm, phase 2 exploratory study

This multicentre, two-arm, phase 2 study aimed to explore the efficacy and safety of neoadjuvant camrelizumab plus chemotherapy or apatinib in patients with initially unresectable stage II–III non-small-cell l...

Haoran **a, Han Zhang, Zheng Ruan… in Signal Transduction and Targeted Therapy (2024)

Article

Nonconserved epitopes dominate reverse preexisting T cell immunity in COVID-19 convalescents

The herd immunity against SARS-CoV-2 is continuously consolidated across the world during the ongoing pandemic. However, the potential function of the nonconserved epitopes in the reverse preexisting cross-rea...

**n Wang, Jie Zhang, Maoshun Liu, Yuanyuan Guo… in Signal Transduction and Targeted Therapy (2024)

Article

Correction: Anti-lymphangiogenesis for boosting drug accumulation in tumors

Chunling Wang, Junchao Xu, **aoyu Cheng, Ge Sun… in Signal Transduction and Targeted Therapy (2024)

Article

First-line penpulimab (an anti-PD1 antibody) and anlotinib (an angiogenesis inhibitor) with nab-paclitaxel/gemcitabine (PAAG) in metastatic pancreatic cancer: a prospective, multicentre, biomolecular exploratory, phase II trial

Metastatic pancreatic cancer (mPC) has a dismal prognosis. Herein, we conducted a prospective, multicentre, single-arm, phase II trial evaluating the efficacy and safety of penpulimab and anlotinib in combinat...

Huizi Sha, Fan Tong, Jiayao Ni, Yi Sun… in Signal Transduction and Targeted Therapy (2024)

Article

Antitumor efficacy and potential mechanism of FAP-targeted radioligand therapy combined with immune checkpoint blockade

Radiotherapy combined with immune checkpoint blockade holds great promise for synergistic antitumor efficacy. Targeted radionuclide therapy delivers radiation directly to tumor sites. LNC1004 is a fibroblast a...

Liang Zhao, Yizhen Pang, Yangfan Zhou… in Signal Transduction and Targeted Therapy (2024)

Article

Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets

The immune response holds a pivotal role in cardiovascular disease development. As multifunctional cells of the innate immune system, macrophages play an essential role in initial inflammatory response that oc...

Runkai Chen, Hongrui Zhang, Botao Tang… in Signal Transduction and Targeted Therapy (2024)

Article

Initial COVID-19 severity influenced by SARS-CoV-2-specific T cells imprints T-cell memory and inversely affects reinfection

The immunoprotective components control COVID-19 disease severity, as well as long-term adaptive immunity maintenance and subsequent reinfection risk discrepancies across initial COVID-19 severity, remain uncl...

Gang Yang, **peng Cao, Jian Qin, **nyue Mei… in Signal Transduction and Targeted Therapy (2024)

Article

Notch signaling pathway in cancer: from mechanistic insights to targeted therapies

Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue homeostasis across metazoans, is highly conserved throughout evolution. The Notch receptor and its ligands are tran...

Qingmiao Shi, Chen Xue, Yifan Zeng, **n Yuan… in Signal Transduction and Targeted Therapy (2024)

Article

DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure

DEAD-box helicase 17 (DDX17) is a typical member of the DEAD-box family with transcriptional cofactor activity. Although DDX17 is abundantly expressed in the myocardium, its role in heart is not fully understo...

Ming**g Yan, Junpeng Gao, Ming Lan, Que Wang… in Signal Transduction and Targeted Therapy (2024)

Article

High-resolution spatiotemporal map**: a comprehensive view of eukaryotic cell cycle proteome dynamics

**g Zou, Ziran Qin, Long Zhang in Signal Transduction and Targeted Therapy (2024)

Article

Development of pharmacological immunoregulatory anti-cancer therapeutics: current mechanistic studies and clinical opportunities

Immunotherapy represented by anti-PD-(L)1 and anti-CTLA-4 inhibitors has revolutionized cancer treatment, but challenges related to resistance and toxicity still remain. Due to the advancement of immuno-oncolo...

Nanhao Yin, **ntong Li, Xuanwei Zhang… in Signal Transduction and Targeted Therapy (2024)

Article

Tumor biomarkers for diagnosis, prognosis and targeted therapy

Tumor biomarkers, the substances which are produced by tumors or the body’s responses to tumors during tumorigenesis and progression, have been demonstrated to possess critical and encouraging value in screeni...

Yue Zhou, Lei Tao, Jiahao Qiu, **g Xu… in Signal Transduction and Targeted Therapy (2024)

Article

PARP1-DNA co-condensation: the driver of broken DNA repair

**ang Wei, Fangfang Zhou, Long Zhang in Signal Transduction and Targeted Therapy (2024)