6 Result(s)
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Article
Open AccessDevelopment of the catfish 250K SNP array for genome-wide association studies
Quantitative traits, such as disease resistance, are most often controlled by a set of genes involving a complex array of regulation. The dissection of genetic basis of quantitative traits requires large numbe...
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Article
Open AccessA hemodialysis cohort study of protocol-based anticoagulation management
Chronic hemodialysis patients frequently require anticoagulation treatment with warfarin for a variety of co-morbidities. The optimal method for monitoring and dose adjustment of warfarin-based anticoagulation...
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Article
Open AccessUsing FFPE RNA-Seq with 12 marker genes to evaluate genotoxic and non-genotoxic rat hepatocarcinogens
Various challenges have been overcome with regard to applying ‘omics technologies for chemical risk assessments. Previously we published results detailing targeted mRNA sequencing (RNA-Seq) on a next generatio...
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Article
Open AccessSeqEnhDL: sequence-based classification of cell type-specific enhancers using deep learning models
To address the challenge of computational identification of cell type-specific regulatory elements on a genome-wide scale.
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Article
Open AccessNew homozygous gpt delta transgenic rat strain improves an efficiency of the in vivo mutagenicity assay
Gene mutation assays in transgenic rodents are useful tools to investigate in vivo mutagenicity in a target tissue. Using a lambda EG10 transgene containing reporter genes, gpt delta transgenic mice and rats have...
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Article
Open AccessPIG-A gene mutation as a genotoxicity biomarker in polycyclic aromatic hydrocarbon-exposed barbecue workers
The PIG-A gene mutation assay is a valuable tool for measuring in vivo gene mutations in blood cells. The human PIG-A assay, used as a potential genotoxicity biomarker, is minimally invasive, sensitive, and cost-...
