36 Result(s)

Article

Structure-guided conversion from an anaplastic lymphoma kinase inhibitor into Plasmodium lysyl-tRNA synthetase selective inhibitors

Aminoacyl-tRNA synthetases (aaRSs) play a central role in the translation of genetic code, serving as attractive drug targets. Within this family, the lysyl-tRNA synthetase (LysRS) constitutes a promising anti...

**tong Zhou, Mingyu **a, Zhenghui Huang, Hang Qiao, Guang Yang… in Communications Biology (2024)

Article

Diagnostic value of BHI-V4 for heterogeneous and vancomycin-intermediate Staphylococcus aureus isolates: a systematic review and meta-analysis

Brain-heart infusion agar supplemented with 4 µg/mL of vancomycin (BHI-V4) was commonly used for the detection of heterogeneous (hVISA) and vancomycin-intermediate Staphylococcus aureus (VISA). However, its diagn...

**n Cheng, Juntong Zhou, Fan Yuan, **gxin Ma, Shuilong Guo… in BMC Infectious Diseases (2024)

Article

Author Correction: Optogenetic-controlled immunotherapeutic designer cells for post-surgical cancer immunotherapy

Yuanhuan Yu, **n Wu, Meiyan Wang, Wen**g Liu, Li Zhang… in Nature Communications (2024)

Article

Stress affects navigation strategies in immersive virtual reality

There are known individual differences in both the ability to learn the layout of novel environments and the flexibility of strategies for navigating known environments. However, it is unclear how navigational...

Apurv Varshney, Mitchell E. Munns, Justin Kasowski, Mantong Zhou… in Scientific Reports (2024)

Article

Recent Advances in Understanding Multi-scale Climate Variability of the Asian Monsoon

Studies of the multi-scale climate variability of the Asian monsoon are essential to an advanced understanding of the physical processes of the global climate system. In this paper, the progress achieved in th...

Wen Chen, Renhe Zhang, Renguang Wu, Zhi** Wen… in Advances in Atmospheric Sciences (2023)

Article

PRR15 deficiency facilitates malignant progression by mediating PI3K/Akt signaling and predicts clinical prognosis in triple-negative rather than non-triple-negative breast cancer

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast neoplasms with a higher risk of recurrence and metastasis than non-TNBC. Nevertheless, the factors responsible for the differences ...

Fengzhu Guo, Jialu Ma, Cong Li, Shuning Liu, Weizheng Wu… in Cell Death & Disease (2023)

Article

Loss of TTC17 promotes breast cancer metastasis through RAP1/CDC42 signaling and sensitizes it to rapamycin and paclitaxel

Breast cancer (BC) metastasis is the leading cause of poor prognosis and therapeutic failure. However, the mechanisms underlying cancer metastasis are far from clear.

**gyao Zhang, Fengzhu Guo, Chunxiao Li, Yang Wang, **song Wang… in Cell & Bioscience (2023)

Article

Improvements in 2D p-type WSe₂ transistors towards ultimate CMOS scaling

This paper provides comprehensive experimental analysis relating to improvements in the two-dimensional (2D) p-type metal–oxide–semiconductor (PMOS) field effect transistors (FETs) by pure van der Waals (vdW) ...

Naim Hossain Patoary, **g **e, Guantong Zhou, Fahad Al Mamun… in Scientific Reports (2023)

Article

Tyrosine-targeted covalent inhibition of a tRNA synthetase aided by zinc ion

Aminoacyl-tRNA synthetases (AARSs), a family of essential protein synthesis enzymes, are attractive targets for drug development. Although several different types of AARS inhibitors have been identified, AARS ...

Hang Qiao, Mingyu **a, Yiyuan Cheng, **tong Zhou, Li Zheng… in Communications Biology (2023)

Article

Optogenetic-controlled immunotherapeutic designer cells for post-surgical cancer immunotherapy

Surgical resection is the main treatment option for most solid tumors, yet cancer recurrence after surgical resection remains a significant challenge in cancer therapy. Recent advances in cancer immunotherapy ...

Yuanhuan Yu, **n Wu, Meiyan Wang, Wen**g Liu, Li Zhang… in Nature Communications (2022)

Article

Dysregulated ceramides metabolism by fatty acid 2-hydroxylase exposes a metabolic vulnerability to target cancer metastasis

Whereas it is appreciated that cancer cells rewire lipid metabolism to survive and propagate, the roles of lipid metabolism in metastasis remain largely unknown. In this study, using esophageal squamous cell c...

Xuantong Zhou, Furong Huang, Gang Ma… in Signal Transduction and Targeted Therapy (2022)

Article

A microRNA-based liquid biopsy signature for the early detection of esophageal squamous cell carcinoma: a retrospective, prospective and multicenter study

Currently, there is no clinically relevant non-invasive biomarker for early detection of esophageal squamous cell carcinoma (ESCC). Herein, we established and evaluated a circulating microRNA (miRNA)-based sig...

**sei Miyoshi, Zhongxu Zhu, Ai** Luo, Shusuke Toden, Xuantong Zhou… in Molecular Cancer (2022)

Article

Incidence, characteristics, and outcomes of delirium in patients with noninvasive ventilation: a prospective observational study

Factors that may increase the risk for delirium and the firm knowledge around mechanism for delirium in noninvasive ventilation (NIV) patients is lacking. We investigated the incidence, characteristics, and ou...

Rui Zhang, Linfu Bai, **aoli Han, Shicong Huang, Lintong Zhou… in BMC Pulmonary Medicine (2021)

Article

Heritable gene editing using FT mobile guide RNAs and DNA viruses

The virus-induced genome editing (VIGE) system can be used to quickly identify gene functions and generate knock-out libraries as an alternative to the virus-induced gene silencing (VIGS). Although plant virus...

Jianfeng Lei, Peihong Dai, Yue Li, Wanqi Zhang, Guantong Zhou, Chao Liu… in Plant Methods (2021)

Article

Comparative transcriptomic and metabolomic analyses of carotenoid biosynthesis reveal the basis of white petal color in Brassica napus

The molecular mechanism underlying white petal color in Brassica napus was revealed by transcriptomic and metabolomic analyses.

Ledong Jia, Junsheng Wang, Rui Wang, Mouzheng Duan, Cailin Qiao, Xue Chen… in Planta (2021)