7 Result(s)
within
English
Medicine & Public Health
Medicine/Public Health, general
**ngyu Huang
-
Article
Cysteine residues in the C-terminal lobe of Src: their role in the suppression of the Src kinase
To evaluate the function of cysteine residues of the Src kinase, we constructed a series of Src mutants in which some of cyteines were replaced to alanines. With these mutants, we studied the effect of SH-alky...
-
Article
Open AccessAllogeneic mesenchymal stem cell as induction therapy to prevent both delayed graft function and acute rejection in deceased donor renal transplantation: study protocol for a randomized controlled trial
Using kidneys from deceased donors is an available strategy to meet the growing need of grafts. However, higher incidences of delayed graft function (DGF) and acute rejection exert adverse effects on graft out...
-
Article
Allogeneic hematopoietic stem cell transplantation overcome the poor prognosis of patients with IKZF1plus CD20–a very high-risk subtype in B-cell acute lymphoblastic leukemia
Genetic deletions of IKZF1 (IKZF1del) and IKZF1del plus other mutations (IKZF1plus) have been identified in B-cell acute lymphoblastic leukemia (B-ALL) with a poor prognosis. Herein, we investigated the combinati...
-
Article
Open AccessSingle-cell RNA-sequencing reveals radiochemotherapy-induced innate immune activation and MHC-II upregulation in cervical cancer
Radiochemotherapy (RCT) is a powerful treatment for cervical cancer, which affects not only malignant cells but also the immune and stromal compartments of the tumor. Understanding the remodeling of the local ...
-
Article
Open AccessIntestinal dysbiosis exacerbates the pathogenesis of psoriasis-like phenotype through changes in fatty acid metabolism
The intestinal microbiota has been associated with host immunity as well as psoriasis; however, the mechanism of intestinal microbiota regulating psoriasis needs to be demonstrated systematically. Here, we sou...
-
Article
Open AccessSlee** more than 8 h: a silent factor contributing to decreased muscle mass in Chinese community-dwelling older adults
Muscle mass loss is an age-related process that can be exacerbated by lifestyle, environmental and other factors, but can be mitigated by good sleep. The objective of this study was to investigate the correlat...
-
Article
Physiological principles underlying the kidney targeting of renal nanomedicines
Kidney disease affects more than 10% of the global population and is associated with considerable morbidity and mortality, highlighting a need for new therapeutic options. Engineered nanoparticles for the trea...
