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Article
FAM98A is localized to stress granules and associates with multiple stress granule-localized proteins
Stress granules are evolutionally conserved ribonucleoprotein structures that are formed in response to various stress stimuli. Recent studies have demonstrated that proteins with low complexity (LC) regions p...
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Article
Erratum to: FAM98A is a novel substrate of PRMT1 required for tumor cell migration, invasion and colony formation
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Article
Erratum to: UBE2S is associated with malignant characteristics of breast cancer cells
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Article
FAM98A is a novel substrate of PRMT1 required for tumor cell migration, invasion, and colony formation
Protein arginine methylation, which is mediated by a family of protein arginine methyltransferases (PRMTs), is associated with numerous fundamental cellular processes. Accumulating studies have revealed that t...
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Article
UBE2S is associated with malignant characteristics of breast cancer cells
Ubiquitination is essential for various biological processes, such as signal transduction, intracellular trafficking, and protein degradation. Accumulating evidence has demonstrated that ubiquitination plays a...
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Article
YAP is essential for tissue tension to ensure vertebrate 3D body shape
D’Arcy Thompson predicted a century ago that animal body shape is conditioned by gravity, but there has been no animal model to study how cellular forces are coordinated to generate body shapes that withstand ...
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Article
Open AccessPlasma-activated medium suppresses choroidal neovascularization in mice: a new therapeutic concept for age-related macular degeneration
Choroidal neovascularization (CNV) is the main pathogenesis of age-related macular degeneration (AMD), which leads to severe vision loss in many aged patients in most advanced country. CNV compromises vision v...
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Article
Quantitative metabolome analysis profiles activation of glutaminolysis in glioma with IDH1 mutation
Isocitrate dehydrogenase 1 (IDH1), which localizes to the cytosol and peroxisomes, catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate (α-KG) and in parallel converts...
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Article
Silencing of TBC1D15 promotes RhoA activation and membrane blebbing
Membrane blebs are round-shaped dynamic membrane protrusions that occur under many physiological conditions. Membrane bleb production is primarily controlled by actin cytoskeletal rearrangements mediated by Rh...
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Article
Peptide-based inhibition of the HOXA9/PBX interaction retards the growth of human meningioma
Meningiomas are the most common type of intracranial tumor, accounting for between 24 and 30 % of primary intracranial tumors. Thus far, no biomarkers exist to reliably predict the clinical outcome of meningio...
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Article
The expression and characterization of endoglin in uterine leiomyosarcoma
Endoglin (CD105), an accessory receptor of transforming growth factor-β, is expressed in vascular endothelial cells. Recently, it was reported that endoglin expression was significantly associated with poorer ...
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Article
S100A10 is required for the organization of actin stress fibers and promotion of cell spreading
Dynamic remodeling of the actin cytoskeleton is crucial for biological processes such as cell migration and cell spreading. S100A10 is a member of the S100 protein family and is involved in intracellular traff...
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Article
Cysteine residues in the C-terminal lobe of Src: their role in the suppression of the Src kinase
To evaluate the function of cysteine residues of the Src kinase, we constructed a series of Src mutants in which some of cyteines were replaced to alanines. With these mutants, we studied the effect of SH-alky...
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Article
A role for SHPS-1/SIRPα1 in IL-1β- and TNFα-dependent signaling
We investigated the role of SHPS-1/SIRPα1 in IL-1β- and TNFα-dependent signaling that leads to the activation of Erk 1/2 and Akt. Treatment of Balb3T3 cells with IL-1β or TNFα activated tyrosine phosphorylatio...
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Article
Stat3-dependent induction of BATF in M1 mouse myeloid leukemia cells
Stat3 mediates cellular responses associated with proliferation, survival and differentiation, but the mechanisms underlying the diverse effects of this signaling molecule remain unknown. M1 mouse myeloid leuk...
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Article
The JAK-inhibitor, JAB/SOCS-1 selectively inhibits cytokine-induced, but not v-Src induced JAK–STAT activation
Recently, constitutive activation of JAK kinases (JAKs) and/or signal transducers and activators of transcription (STATs) has been reported in growing numbers of human cancer cells as well as oncogene-transfor...
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Article
v-Src suppresses SHPS-1 expression via the Ras-MAP kinase pathway to promote the oncogenic growth of cells
We investigated the effect of cell transformation by v-src on the expression and tyrosine phosphorylation of SHPS-1, a putative docking protein for SHP-1 and SHP-2. We found that transformation by v-src virtually...
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Article
Clustered cysteine residues in the kinase domain of v-Src: critical role for protein stability, cell transformation and sensitivity to herbimycin A
We have previously reported the activation of Src by mercuric chloride based on the sulfhydryl modification. To evaluate the significance of cysteine residues in v-Src, we replaced each cysteine to alanine by ...
