9 Result(s)

Article

Mining of a streptothricin gene cluster from Streptomyces sp. TP-A0356 genome via heterologous expression

Streptothricins (STs) are used commercially to treat bacterial and fungal diseases in agriculture. Mining of the sequenced microbial genomes uncovered two cryptic ST clusters from Streptomyces sp. C and Streptomy...

**E Li, ZhengYan Guo, Wei Huang, **ang** Meng, GuoMin Ai… in Science China Life Sciences (2013)

Article

Zika virus and neural developmental defects: building a case for a cause

Sarah C. Ogden, Christy Hammack, Hengli Tang in Science China Life Sciences (2016)

Article

1-Methyl-tryptophan attenuates regulatory T cells differentiation due to the inhibition of estrogen-IDO1-MRC2 axis in endometriosis

Foxp3⁺ regulatory T (T_reg) cells contribute to the local dysfunctional immune environment in endometriosis, an estrogen-dependent gynecological disease, which affects the function of ectopic endometrial tissue cl...

Chunyan Wei, Jie Mei, Lingli Tang, Yukai Liu, Da** Li, Mingqing Li… in Cell Death & Disease (2016)

Article

Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry

The re-emergence of Zika virus (ZIKV) and Ebola virus (EBOV) poses serious and continued threats to the global public health. Effective therapeutics for these maladies is an unmet need. Here, we show that emet...

Shu Yang, Miao Xu, Emily M Lee, Kirill Gorshkov, Sergey A. Shiryaev… in Cell Discovery (2018)

Article

Biological activity-based modeling identifies antiviral leads against SARS-CoV-2

Computational approaches for drug discovery, such as quantitative structure–activity relationship, rely on structural similarities of small molecules to infer biological activity but are often limited to ident...

Ruili Huang, Miao Xu, Hu Zhu, Catherine Z. Chen, Wei Zhu… in Nature Biotechnology (2021)

Article

Distribution, characterization, and antibiotic resistance of hypervirulent Klebsiella pneumoniae isolates in a Chinese population with asymptomatic bacteriuria

Asymptomatic bacteriuria (ASB) frequently occurs among all ages and may develop into urinary tract infections (UTIs). Hypervirulent Klebsiella pneumoniae (hvKP) has become a new threat to human health. In our stu...

Jun Li, Yanbing Li, Mengli Tang, Fengjun **a, Changhang Min, Yongmei Hu… in BMC Microbiology (2022)

Article

Emergence of polymyxin B-heteroresistant hypervirulent Klebsiella pneumoniae from an individual in the community with asymptomatic bacteriuria

The heteroresistance of polymyxin B, a last-resort antibiotic used to treat many serious bacterial infections, may lead to antibiotic treatment failure. However, polymyxin B-heteroresistant isolates are rare i...

Jun Li, Mengli Tang, Fengjun **a, Changhang Min, Yongmei Hu… in BMC Microbiology (2022)

Article

Clonal transmission of polymyxin B-resistant hypervirulent Klebsiella pneumoniae isolates coharboring bla_NDM-1 and bla_KPC-2 in a tertiary hospital in China

The prevalence of multidrug-resistant hypervirulent K. pneumoniae (MDR-hvKP) has gradually increased. It poses a severe threat to human health. However, polymyxin-resistant hvKP is rare. Here, we collected eight ...

Mengli Tang, Jun Li, Zhaojun Liu, Fengjun **a, Changhang Min… in BMC Microbiology (2023)